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題名 | Evaluation of Carotenoid Extract from Dunaliella salina against Cadmium-Induced Cytotoxicity and Transforming Growth Factor β1 Induced Expression of Smooth Muscle α-Actin with Rat Liver Cell Lines=以老鼠肝臟細胞株評估杜莎藻(Dunaliella salina)類胡蘿蔔素萃取物抗鎘誘發之細胞毒性和轉形生長因子誘發之平滑肌 α 肌動蛋白表現 |
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作者姓名(中文) | 林昭田; 李英中; 胡超群; 沈祐成; 呂峰州; 楊登傑; | 書刊名 | Journal of Food and Drug Analysis |
卷期 | 18:5 2010.10[民99.10] |
頁次 | 頁301-306+367 |
分類號 | 411.38 |
關鍵詞 | 鎘; 類胡蘿蔔素; 細胞毒性; 杜莎藻; HSC-T6細胞; Clone 9細胞; HPLC分析; 平滑肌α肌動蛋白; 轉形生長因子; Cadmium; Carotenoid; Cytotoxicity; Dunaliella salina; HSC-T6 cells; Clone 9 cells; HPLC analysis; Smooth muscle α-actin; Transforming growth factor β1; TGF-β1; αSMA; |
語文 | 英文(English) |
英文摘要 | ABSTRACT The carotenoid extract from Dunaliella salina was identified and quantitated. The effects against cadmium (Cd)-induced hepatotoxicity and transforming growth factor β1 (TGF-β1)-induced activation of hepatic stellate cells (HSCs) were evaluated. All-trans-β-carotene (474.82 mg/g extract) and 9- or 9′-cis-β-carotene (425.64 mg/g extract) were major carotenoids in the extract, accounting for 90.30% of total carotenoids (997.17 mg/g extract). Other carotenoids were all-trans-lutein (22.77 mg/g extract), all-trans-zeaxanthin (39.26 mg/g extract), 13- or 13′-cis-β-carotene (17.18 mg/g extract), all-trans-α-carotene (9.26 mg/g extract) and 9- or 9′-cis-α-carotene (8.24 mg/g extract). The algal extract had a higher effect (p < 0.05) than all-trans-β-carotene in the reduction of cytotoxicity for CdCl2-treated Clone 9 cells and expression of smooth muscle α-actin (αSMA) for TGF-β1-treated HSC-T6 cells. These effects were shown to be concentration-dependent. |
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