頁籤選單縮合
題 名 | Acute Pathophysiological Effects of Intratracheal Instillation of Budesonide and Exogenous Surfactant in a Neonatal Surfactant-Depleted Piglet Model |
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作 者 | Yang, Chia-feng; Jeng, Mei-jy; Soong, Wen-jue; Lee, Yu-sheng; Tsao, Pen-chen; Tang, Ren-bin; | 書刊名 | Pediatrics and Neonatology |
卷 期 | 51:4 2010.08[民99.08] |
頁 次 | 頁219-226 |
分類號 | 417.5 |
關鍵詞 | Budesonide; Corticosteroid; Piglet; Respiratory distress syndrome; Surfactant; |
語 文 | 英文(English) |
英文摘要 | There has been concern over the effect of vigorous bubbling on the delivery pressure during the operation of the bubble nasal continuous positive airway pressure (CPAP) system. We investigated the relationship between intra-tubing pressure changes and flow rates in a closed bubble CPAP system in vitro. Methods Using an experimental (in vitro) model, the distal connecting tube of the CPAP system was immersed under the water seal to a depth of 5 cm. Sixteen different flow rates, ranging from 2 L/min to 20 L/min, were tested. The procedure was repeated 10 times at each flow rate, and the intra-tubing pressure was recorded. Results The intra-tubing pressure within the model increased as the air flow rates were adjusted from 2 L/min to 20 L/min. The relationship was represented by the following equation, pressure (cmH2O) = 5.37 + 0.15 × flow rate (L/min) (R2 = 0.826, p < 0.001). Conclusion These results demonstrated that the intra-tubing pressure in a bubble CPAP system was highly correlated with flow rate in vitro. |
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