查詢結果分析
來源資料
相關文獻
- 泌乳素的生理和高泌乳素血症
- 泌乳素瘤的診斷與治療
- 腦下腺前葉同種移植誘發慢性血泌乳素過高症對雄性大白鼠在低溫束縛條件下引發胃潰瘍之影響
- Collagenolytic Enzymes and Progestin in Induced Ovulation in Rabbits with Hyperprolactinemia
- Study of the LH/FSH ratio and pituitary function in the hyperprolactinemic patients
- 甲狀腺功能低下症相關之高泌乳素血症--二病例報告與文獻回顧
- Etiologies and Clinical Manifestations of Hyperprolactinemia in a Medical Center in Southern Taiwan
- Risperidone可能引起高泌乳素血症與男性女乳症
- 中西醫治療高泌乳素血症引起月經失調之病案報告
- 伴有巨大內頸動脈瘤之腦下垂體功能低下及高泌乳素血症--一病例報告
頁籤選單縮合
題名 | 泌乳素的生理和高泌乳素血症=Physiology of Prolactin and Hyperprolactinemia |
---|---|
作者 | 邱司漢; 吳令怡; | 書刊名 | 內科學誌 |
卷期 | 21:5 2010.10[民99.10] |
頁次 | 頁305-321 |
分類號 | 415.663 |
關鍵詞 | 泌乳素; 高泌乳素血症; 泌乳素瘤; 多巴胺促效劑; 腦下腺; Prolactin; Hyperprolactinemia; Prolactinoma; Dopamine agonists; Pituitary; |
語文 | 中文(Chinese) |
中文摘要 | 泌乳素(prolactin)是以一種脈衝的方式所分泌的激素。正常的個體一天中大約有14個分泌 波峰。除此之外,泌乳素的分泌量亦有日夜的差異,亦即與周圍環境的光暗週期有關。夜間 睡眠時,特別是在非快速動眼期(non- rapid eye movement)呈現較高量的分泌。在人類懷孕和 泌乳期,泌乳素的主要作用是刺激乳汁分泌。高泌乳素血症(hyperprolactinemia)是內分泌科 和婦產科最常見的下視丘-腦下腺軸疾病。造成原因包括最常見的泌乳素瘤(prolactinoma)及 其他次發性和生理性過度分泌。懷疑泌乳素瘤要先排除藥物、甲狀腺功能低下、肝腎疾病、 多囊性卵巢症等等。臨床症狀包括溢乳、性腺功能低下,如果是巨泌乳素瘤,可能壓迫到視 交叉造成頭痛、視野缺損。病患如有溢乳、月經不規則、不孕、性無能、性腺功能低下等明 顯症狀和為了預防骨質疏鬆,可考慮治療。多巴胺促效劑(dopamine agonists)可讓大部分病患 泌乳素恢復正常,其他治療方法包括手術和放射治療,但皆有其限制。泌乳素瘤的懷孕病患 在妊娠期需要謹慎地追蹤。 |
英文摘要 | Prolactin is a pulsatile, not a static, hormone. Prolactin secretion occurs episodically in 14 secretory pulses over 24 hours. It has a circadian fluctuation, with the highest levels achieving between 4 and 6 am and the lowest occurring between 10 am and noon. The nocturnal elevation is sleep entrained, especially in non-rapid eye movement sleep (REM). It is essential for human species survival by milk production during pregnancy and lactation. Hyperprolactinemia is the most common hypothalamic-pituitary disorder encountered in clinical endocrinology, obstetrics and gynaecology. Hyperprolactinemia may be due to a prolactinoma, secondary to other causes and physiologic hypersecretion. The most common cause of hyperprolactinemia is prolactinoma. Secondary to other causes including drug effects, renal disease, liver disease, hypothyroidism and polycystic ovary syndrome should be ruled out before investigating prolactinoma. They present with clinical features of hyperprolactinemia (galactorrhea, gonadal hypofunction). Headache and visual field defects due to optic chiasm compression are common in patients who have macroprolactinomas. Indications for treatment would contain the presence of confusing symptoms, such as menstrual disturbance, bothersome galactorrhea, infertility, impotence, long-lasting hypogonadism, and prevention of bone loss. Medical therapy with dopamine agonists is well responsive in achieving normoprolactinemia in most patients, and other methods of treatment such as surgery and radiotherapy currently have many limited indications. The pregnant women with prolactinomas need careful planning and close monitoring |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。