頁籤選單縮合
題名 | Screening for Anti-lipase Properties of 37 Traditional Chinese Medicinal Herbs=中藥中脂解酶抑制劑的篩選 |
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作者 | 鄭成棟; 段亞青; 高錦明; 阮志剛; | 書刊名 | Journal of the Chinese Medical Association |
卷期 | 73:6 2010.06[民99.06] |
頁次 | 頁319-324+CA56 |
關鍵詞 | 抗脂解酶活性; 抗肥胖; 夏枯草; 大黃; 中草藥; Anti-lipase activity; Anti-obesity agents; Chinese herbal drugs; Prunella vulgaris L.; Rheum palmatum L.; |
語文 | 英文(English) |
英文摘要 | Background: To find new, crude anti-obesity drugs from natural sources through the inhibition of adsorption of dietary lipids, in vitro porcine pancreatic lipase (PPL; triacylglycerol lipase, EC 3.1.1.3) inhibitory tests were carried out on selected plants with weight-reducing or related potential, used in Chinese traditional medicine. Methods: The methanolic extracts of 37 traditional Chinese herbal medicines of different families were assayed for their in vitro activity against PPL by using spectrophotometry with 2,4-dinitrophenyl butyrate as a synthetic substrate. Coexistent phytochemicals, or those present in high levels, in the 3 most promising Chinese herbs were tested for their anti-lipase activity. Results: Extracts from 2 herbs, Prunella vulgaris L. (Labiatae) and Rheum palmatum L. (Polygonaceae), at a concentration of 200 μg/mL, significantly inhibited PPL—by 74.7% and 53.8%, respectively. Quercetin exhibited better activity (27.4%) than all the other phytochemicals at a final concentration of 25 μg/mL in the assay system, followed by luteolin, with an activity of 17.3%. Conclusion: The results support the view that herbs represent a rich source of anti-lipase compounds. The screening of the methanolic extracts of 37 Chinese medicinal plants in vitro led to the identification of several extracts with potential activity against PPL, in particular, P. vulgaris and R. palmatum. We also found that several monomeric chemicals in these herbs exhibited good or moderate activity against PPL. To the best of our knowledge, these traditional Chinese herbal medicines or phytochemicals have not been previously screened for their lipase inhibitory activity. |
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