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題名 | Hepatitis B Virus Reactivation After 23 Months of Rituximab-based Chemotherapy in an HBsAg-negative, Anti-HBs-positive Patient With Follicular Lymphoma=B型肝炎表面抗原陰性,核心抗原陽性之濾泡型淋巴瘤病患接受Rituximab化學治療二十三個月後發生B型肝炎病毒復發 |
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作者 | 李懿宬; 黃怡翔; 朱啟仁; 李培正; 林漢傑; 李壽東; | 書刊名 | Journal of the Chinese Medical Association |
卷期 | 73:3 2010.03[民99.03] |
頁次 | 頁156-160+CA26 |
分類號 | 415.415 |
關鍵詞 | 核心抗體陽性; 化學治療; B型肝炎復發; 淋巴瘤; Rituximab; Anti-HBc positive; Chemotherapy; HBV reactivation; Non-Hodgkin’s lymphoma; |
語文 | 英文(English) |
英文摘要 | A 72-year-old female negative for hepatitis B surface antigen (HBsAg) and positive for antibody to hepatitis B surface antigen (anti-HBs) was diagnosed to have follicular lymphoma in 2006. Seventeen cycles of rituximab-based chemotherapy were administered over 23 months. Twelve days after the last cycle of chemotherapy, serum aminotransferase levels were elevated, and hepatitis serology tests revealed reappearance of HBsAg and hepatitis B e antigen (HBeAg), loss of anti-HBs, and positivity for hepatitis B virus (HBV) DNA. Antiviral treatment with entecavir was administered immediately, and the hepatitis flare was controlled. Rituximab-based chemotherapy can induce HBV reactivation even in HBsAg-negative, anti-HBs-positive patients. Early recognition and prompt antiviral treatment is crucial for patients with HBV reactivation during anticancer therapy. |
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