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題 名 | Novel Application of Artificial Dermis Plus Autologous Vital Epithelial Cells: Improved Wound Epithelialization=簡便自體上皮細胞作為人工植皮材料之應用 |
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作 者 | 李立慈; 關寶祥; 黃穰基; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 73:2 2010.02[民99.02] |
頁 次 | 頁108-112+CA20 |
分類號 | 416.98 |
關鍵詞 | 人工皮; 表皮化; 疤痕收縮; 鱗狀上皮細胞癌; 組織工程學; Artificial dermis; Epithelialization; Scar contraction; Squamous cell carcinoma; Tissue engineering; |
語 文 | 英文(English) |
英文摘要 | The purpose of this study was to evaluate artificial dermis with the simultaneous addition of autologous epithelial cells for oral lesion defect reconstruction. Surgical wounds reconstructed with artificial dermis plus scraped epithelial cells were evaluated in 5 patients with oral benign lesions or squamous cell carcinoma. Clinical follow-up indices included scar formation and tissue surface texture observation. The neomucosal layers were analyzed histologically to establish the degree of epithelialization. Clinical observation showed that the oral mucosal texture was smoother in artificial dermis with added epithelial cells at 4 weeks postoperation compared with artificial dermis alone. The wound contraction and scar formation processes were slow. Viable epithelial cells with flat rete ridges remained in the artificial dermis, and a neoepithelial layer was present in the histological findings. We showed that healthy granulation tissue and neoepithelial formation in artificial dermis with epithelial cells was beneficial for the repair of oral defects. Scraping oral epithelial cells and applying them to artificial dermis assisted in the early preparation of composite grafts and minimized requirement for donor sites. This technique may improve the treatment of patients with oral benign tumors and early-stage squamous cell carcinoma. |
本系統中英文摘要資訊取自各篇刊載內容。