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題 名 | Prophylactic Antibiotic Administration Induced Bronchospasm as Increased Airway Pressure During General Anesthesia=全身麻醉過程中因預防抗生素引起之支氣管痙攣及氣道壓力增加 |
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作 者 | 郭怡敏; 丁乾坤; 王郁傑; 張文貴; 吳欣倫; 陳國瀚; 陳品堂; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 73:2 2010.02[民99.02] |
頁 次 | 頁72-77+CA13 |
分類號 | 416.5 |
關鍵詞 | 氣道壓力; 過敏反應; 抗生素; 支氣管痙攣; 頭孢菌素; 病患安全; Airway pressure; Anaphylactic reaction; Antibiotic; Bronchospasm; Cephalosporin; Patient safety; |
語 文 | 英文(English) |
英文摘要 | BACKGROUND: Anaphylactic reaction induced bronchospasm as wheezing and severe elevation of airway pressure was observed in a succession of patients during general anesthesia at our institute in November 2007. The aim of this survey was to investigate the suspected causes and risk factors of these anaphylactic reactions and the degree of correlation. METHODS: All patients who received general anesthesia between November 1 and November 10, 2007 were enrolled. Underlying diseases, substances including intravenous and inhalational anesthetics, antibiotics, and the degree of increase in airway pressure were recorded. Enrolled patients were divided into a significant-airway-pressure-elevation group (Group P) and a no-airway-pressure-elevation group (Group N). RESULTS: A new brand of cephalexin (Roles®) used as a prophylactic antibiotic was identified as the most likely causative substance of this succession of suspected anaphylactic reactions (28 in 185 patients, 15.14%), and rapid administration was a contributor to these anaphylactic reactions. CONCLUSION: In this study, we found that rapid administration of Roles® was the main cause of suspected anaphylactic reaction presenting as bronchospasm with severe elevated airway pressure. Using Roles® as the prophylactic antibiotic is not recommended in patients receiving general anesthesia. |
本系統中英文摘要資訊取自各篇刊載內容。