頁籤選單縮合
| 題 名 | Elevated Amniotic Fluid Stromal Cell-derived Factor-1 alpha (SDF-1 alpha) Concentration in Mid-gestation as a Predictor of Adverse Birth Outcomes=懷孕中期羊水間質細胞來源因子SDF-1α濃度的增加可作為新生兒預後不良的指標 |
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| 作 者 | 曾振志; 陳雅芳; 謝允廷; 周明明; | 書刊名 | Journal of the Chinese Medical Association |
| 卷 期 | 72:12 2009.12[民98.12] |
| 頁 次 | 頁638-642+CA119 |
| 分類號 | 417.42 |
| 關鍵詞 | 羊水; 妊娠糖尿病; 妊娠毒血症; 懷孕; 第一型間質細胞來源因子; Amniotic fluid; Gestational diabetes; Pre-eclampsia; Pregnancy; Stromal cell-derived factor 1; |
| 語 文 | 英文(English) |
| 英文摘要 | BACKGROUND: This study aimed to predict maternal and neonatal outcomes by measuring mid-trimester amniotic fluid stromal cell-derived factor-1α (SDF-1α) concentration in healthy women. METHODS: Mid-trimester amniotic fluid samples from healthy women with a singleton pregnancy were obtained at the time of genetic amniocenteses. SDF-1α concentrations were determined by enzyme-linked immunosorbent assay. Maternal and neonatal characteristics were recorded. RESULTS: A total of 210 samples were collected. According to the SDF-1α cutoff value established by the receiver operating characteristic curve analysis (< 6.42 vs. ≥ 6.42 pg/mL), there was a trend toward higher preterm birth rate, lower birth weight and lower 1-minute and 5-minute Apgar scores when SDF-1α levels increased (p < 0.05). The pair comparison between normal and selected pregnancy disorders (gestational diabetes, pre-eclampsia, and abnormal placentation) showed no statistical significance (p > 0.05). Pearson’s correlations of SDF-1α to gestational age at delivery (r = –0.151) and birth weight (r = –0.194) were significant (p < 0.05). In the multivariate analysis on mid-trimester SDF-1α levels, maternal age at sampling (regression coefficient = –0.163) and 1-minute Apgar score (< 7 vs. ≥ 7, regression coefficient = 2.028) were both significant (p < 0.05). CONCLUSION: Increased SDF-1α levels in mid-trimester amniotic fluid suggest a possible role in predicting pregnant women at risk of adverse neonatal outcomes including higher preterm birth rate, lower birth weight, and lower Apgar scores. |
本系統中英文摘要資訊取自各篇刊載內容。