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題 名 | Distribution of Hypoxia-Inducible Factor-1α and Bcl-2 : A Study of Varicose Veins by Confocal Microscopy=以共軛焦顯微鏡研究缺氧誘發因子-1α及Bcl-2在下肢靜脈曲張的分佈 |
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作 者 | 易志成; 楊文凱; 李建達; | 書刊名 | 臺灣外科醫學會雜誌 |
卷 期 | 43:5 2010.09-10[民99.09-10] |
頁 次 | 頁229-235 |
分類號 | 416.264 |
關鍵詞 | 下肢靜脈曲張; 共軛焦顯微鏡; HIF-1α; Bcl-2; varicose vein; Confocal microscopy; |
語 文 | 英文(English) |
英文摘要 | Objective : The tissue hypoxia caused by chronic venous insufficiency and blood stasis is the etiology of varicose vein formation. Bcl-2 (anti-apoptotic protein) reduces apoptosis may contribute to the dilated and thickened walls of the diseased vessels. We studied the distribution and relationship of hypoxia-inducible factor-1 α (HIF-1α ) and Bcl-2 in varicose veins by confocal microscopy. Methods : This study consisted of examination of 1cm venous segments (hypertrophic type) from 12 patients obtained during conventional stripping surgery for the varicose saphenous vein in the calf muscle region. All vascular specimens were studied for HIF-1α and Bcl-2 by immunohistochemical stain and confocal laser scanning microscopy. Results : In varicose veins, the immunohistochemical staining of both HIF-1α and Bcl-2 showed strong immunostaining in the hypertrophic smooth muscle layer. In further study, prominent HIF-1α distribution in the muscle layer and Bcl-2 protein deposition in the endothelial layer were demonstrated under confocal laser scanning microscopy. Conclusions : These results revealed prominent HIF-1α and Bcl-2 distribution in the muscle layer with co-localization, and Bcl-2 overexpression in the endothelial layer of varicose vein vessels under confocal microscopy. |
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