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| 題 名 | Citalopram Analysis in Formulation and Urine by a Novel Citalopram Potentiometric Membrane Sensor=新型電位膜傳感器分析製劑及尿液中Citalopram |
|---|---|
| 作 者 | Faridbod, Farnoush; Ganjali, Mohammad Reza; Dinarvand, Rassoul; Riahi, Siavash; Norouzi, Parviz; Olia, Mina Barzegar Amiri; | 書刊名 | Journal of Food and Drug Analysis |
| 卷 期 | 17:4 2009.08[民98.08] |
| 頁 次 | 頁264-273+316 |
| 分類號 | 418.43 |
| 關鍵詞 | 電位傳感器; 聚氯乙烯膜; 離子對; 密度泛函理論; 化學計量學; Potentiometric sensor; PVC membrane; Ion-pair; Citalopram; Density Functional Theory; Chemometrics; |
| 語 文 | 英文(English) |
| 中文摘要 | Citalopram是一種治療情緒失調的抗憂鬱症藥物。本研究介紹一種以聚氯乙烯 (PVC) 膜傳感器為基礎的離子對設計,用以檢測 citalopram。有關膜的製備,以 citalopram-tetraphenyl borate離子對為電學原料。其他塑化劑如 dibutyl phthalate (DBP)、acetophenon (AP)、nitrobenzene (NB)及 nitrophenyloctyl ether (o-NPOE)也都同時納入研究。經由一系列的實驗, 30% PVC、66% DBP及 4%離子對組成的膜,可達最佳電極性能。 citalopram濃度範圍 1×10-5至 1×10-2 M,pH介於 3.0-5.5時,電極展現快速 (~5 s)、穩定能斯特反應 (58.6 ± 0.3 mV/decade)。本研究之確效顯示,傳感器方法簡單、精確且可應用於 HPLC,適合用於分析製劑及尿液中 citalopram hydrobromide。 |
| 英文摘要 | Citalopram is an antidepressant drug used to treat depression associated with mood disorders. This research introduces the design of an ion-pair based polyvinylchloride (PVC) membrane sensor for the citalopram determination based on theoretical investigations. For the membrane preparation, citalopram-tetraphenyl borate ion-pair was employed as an electroactive material in the PVC membrane. In parallel, several plasticizers were studied, i.e. dibutyl phthalate (DBP), acetophenon (AP), nitrobenzene (NB) and nitrophenyloctyl ether (o-NPOE). After a series of experiments, the best electrode performance was accomplished with a membrane composition of 30% PVC, 66% DBP, and 4% ion-pair. This electrode illustrated a fast (~5 s), stable and Nernstian response (58.6 ± 0.3 mV/decade) across a relatively wide citalopram concentration range 1×10-5 to 1×10-2 M and in the pH range of 3.0-5.5. Validation of the method showed suitability of the sensors for the quality control analysis of citalopram hydrobromide in pharmaceutical formulation and urine. The proposed method was simple, accurate and precise and can be used as a detector for HPLC. |
本系統中英文摘要資訊取自各篇刊載內容。