頁籤選單縮合
題名 | 重症肌無力危象之血漿分離療法=Plasmapheresis in Myasthenic Crisis |
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作者姓名(中文) | 葉建宏; 邱浩彰; | 書刊名 | 中華民國重症醫學雜誌 |
卷期 | 11:2 2010.08[民99.08] |
頁次 | 頁80-89 |
分類號 | 415.9413 |
關鍵詞 | 血漿分離術; 肌無力現象; 乙烯膽鹼受體抗體; 雙階正壓呼吸器; 肺功能測試; Plasmapheresis; Myasthenic crisis; Acetylcholine receptor antibody; Bilevel positive airway pressure; Pulmonary function test; |
語文 | 中文(Chinese) |
英文摘要 | To investigate the prognostic factors and outcome of myasthenia gravis (MG) patients in crisis treated with double filtration plasmapheresis (DFP); this study retrospectively reviewed the medical records of 84 MG patients with 123 episodes of crisis treated with DFP. After DFP treatment, the median improvement of MG scores were 4 (-11 to 12 points). The reduction of MG score over two points was considered as a good respond, occurring in 62%. The median duration of crisis were 9 days (1-241 days) and 68% of patients could be weaned from the ventilator within 2 weeks. The post-DFP parameters including MG score, antibody titer, vital capacity and maximal inspiratory pressure correlated well with the duration of crisis. In the group of patients using the endotracheal intubation and conventional mechanical ventilation (ETMV), pneumonia (p = 0.0063), any kind of complication (p = 0.0304), and not receiving thymectomy (p = 0.0238) significantly prolonged the duration of crisis. For the user of bilevel positive airway pressure (BiPAP) ventilator, the duration of crisis and ICU stay were significantly shortened in along with the fewer occurrences of complications of pneumonia and fever as compared to the ETMV group. In conclusion, DFP treatment could ameliorate the profound weakness in crisis and improve the prognosis of crisis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。