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頁籤選單縮合
題 名 | 雙磷酸鹽相關之顎骨壞死與植牙之關聯性=Bisphosphonate-related Osteonecrosis of the Jaws and the Dental Implants |
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作 者 | 吳昭男; 張欣如; 陳宜君; 蘇靜明; 梁世怡; 謝耀東; | 書刊名 | 臺灣牙周病醫學會雜誌 |
卷 期 | 15:1 2010.03[民99.03] |
頁 次 | 頁89-98 |
分類號 | 416.9493 |
關鍵詞 | 骨質疏鬆; 惡性骨轉移; 與雙磷酸鹽相關之顎骨壞死; 口服雙磷酸鹽; 植牙; Osteoporosis; Malignant bone metastases; Bisphosphonate-related osteonecrosis of the jaws; Oral bisphosphonate; Dental implants; |
語 文 | 中文(Chinese) |
中文摘要 | 雙磷酸鹽類 (bisphosphonates) 是用來治療骨質疏鬆 (osteoporosis) 及惡性骨轉移 (malignant bone metastases) 相當有臨床療效的藥物,然而在一部分使用雙磷酸鹽類的患者身上卻發生顎骨壞死 (osteonecrosis of the jaws) 之現象,患者往往在接受拔牙等對齒槽骨較具侵犯性之牙科手術後,於口內出現齒槽骨或顎骨暴露、壞死之現象,不僅手術傷口長時問不癒合,有時還會合併傷口感染,引發嚴重之疼痛,甚至併發顎骨病理性骨折等。使用雙磷酸鹽類藥物併發顎骨壞死現象自2003年被批露後就一直吸引大眾的目光,甚至引發一些使用雙磷酸鹽類民眾之恐慌。本文將就與雙磷酸鹽相關之顎骨壞死的歷史作一回顧,並對不同的雙磷酸鹽投與路徑引發顎骨壞死之機率,及引發顎骨壞死之相關危險因子,及口服雙磷酸鹽 (oral bisphosphonates) 與植牙的關連性,作一文獻回顧。希望讀者在面對使用雙磷酸鹽類藥物且需進行植牙手術的患者時能有所憑藉。 |
英文摘要 | Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. Despite these benefits, osteonecrosis of the jaws is a significant complication in a subset of patients receiving these drugs. This complication usually presents after simple dentoalveolar surgery. Reports first appeared in 2003, there is an increasing number of bisphosphonate-related osteonecrosis of the jaws (BRONJ) cases being diagnosed, and BRONJ is recognized as occurring in all countries where bisphosphonates are prescribed. In this article, we will review the history of BRONJ, the incidence & factors associated with development of BRONJ, the relationship between oral bisphosphonate & dental implants. |
本系統中英文摘要資訊取自各篇刊載內容。