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題 名 | A Perspective View on the Preparation of Micro- and Nanoparticulates of Biomaterials from Electrostatic and Ultrasonic Methods |
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作 者 | Kuo, Shyh Ming; Chang, Shwu Jen; Yao, Chun-hsu; Manousakas, Ioannis; | 書刊名 | Biomedical Engineering: Applications, Basis and Communications |
卷 期 | 21:5 2009.10[民98.10] |
頁 次 | 頁343-353 |
分類號 | 410.01336 |
關鍵詞 | Microspheres; Collagen; Chitosan; Alginate; Tissue regeneration; |
語 文 | 英文(English) |
英文摘要 | Developments on tissue engineering, especially on tissue regeneration and drug delivery, demand also developments on biomaterials. Research on the preparation methods of biomaterials has exhibited remarkable advances in the recent years. Natural biomaterials, such as chitosan and collagen, or synthetic materials like poly(lactic acid) can be shaped in various forms. The parameters involved in the fabrication processes provide methodologies for control of the materials' properties, such as morphology, biodegradability, mechanical strength, and adhesion. As new applications develop for these materials, the preparation methods have to be optimized to achieve the desired material properties. These properties mostly not only mimic the conditions in the human body, but also may divert the microenvironment of cells in the diseased area in order to promote faster or guided healing and tissue regeneration. This review pays attention on some of the fabrication methods for biomaterial particulates of sizes in the micro- and nanoscale. The views expressed here focus on the many years of experience of the authors with electrostatic and ultrasonic fabrication methods. These methods are still under development and up to now can produce particulates of various sizes down to the nanometer scale with narrow size distributions. Such biomaterials that have extraordinary properties may provide ways for the development of remarkable biomedical applications. |
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