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頁籤選單縮合
題 名 | Guillain-Barré症候群之治療=Management of Guillain-Barré Syndrome |
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作 者 | 張美惠; 陳偉立; 鄧新棠; | 書刊名 | 藥學雜誌 |
卷 期 | 26:1=102 2010.03[民99.03] |
頁 次 | 頁26-32 |
分類號 | 415.831 |
關鍵詞 | Guillain-Barré症候群; 血漿置換術; 免疫球蛋白; Guillain-Barré syndrome; Plasmaphoresis; Intravenous immunoglobulin; |
語 文 | 中文(Chinese) |
中文摘要 | Guillain-barré症候群 (GBS)是一種急性週邊神經病變,患者在數天至四週內發生肢體麻痺、對稱性肌肉無力、感覺異常及反射消失等症狀,在感染細菌或病毒後,誘導免疫反應攻擊末梢神經之髓鞘引起的脫髓鞘神經病變及續發性軸突變性,血漿置換術及免疫球蛋白是目前證實有效的兩種治療方式,愈早治療效果越佳,大部份病患在 6-12個月後功能可以完全恢復, 10-20%病患會留下永久性神經後遺症,死亡率約 5-10%。 本文介紹此罕見神經疾病之分類、致病機轉、臨床表徵及治療方式,並探討免疫療法的應用、機轉及副作用的預防及處理。 |
英文摘要 | Guillain-Barre'syndrome (GBS) is an acute peripheral neuropathy which triggered by a preceding bacterial or viral infection following induced immune reaction against in myelin sheath and axonal membrane result in acute inflammatory demyelinating neuropathy and axonal neuropathy. The clinical characterized by acute flaccid paralysis, rapid symmetrical limb weakness, absent or mild sensory signs, loss of tendon reflexes and autonomic dysfunction within several days to 4 weeks.Both plasmaphoresis and iv immunoglobulin have been shown to be effect treatment. The most patients make a complete functional recovery over 6 to 12 months. About 10-20% of patient left with severe disability. Mortality rates were 5-10%. We reviewed this rare neurology disease of classification, pathogenesis, clinical feature and treatment. The clinical literature of immunomodulating treatment, its application, mechanism and adverse effects were discussed. |
本系統中英文摘要資訊取自各篇刊載內容。