查詢結果分析
相關文獻
- Active Compounds in Chinese Herbs and Medicinal Animal Products Which Promote Blood Circulation via Inhibition of Na⁺, K⁺-ATPase
- 中藥有效成分之活血化瘀藥理研究回顧論述
- 人參皂苷Rc對人類精子活動力的體外效應
- Effect of Ginsenoside Rb2 on Human Sperm Motility in Vitro
- 談活血化瘀與前列腺素
- 活血化瘀中藥的臨床運用
- 九節木之活血化瘀活性分析
- 活血化瘀法對於糖尿病病患的研究與發展
- 子宮內膜異位性不孕症病例討論
- 活血化瘀方藥抗大鼠肝纖維化的形態學和組織化學定量研究
頁籤選單縮合
題 名 | Active Compounds in Chinese Herbs and Medicinal Animal Products Which Promote Blood Circulation via Inhibition of Na⁺, K⁺-ATPase=經由抑制鈉鉀幫浦達成行血功能的中藥材有效成分 |
---|---|
作 者 | 曾志正; 陳榮佑; 鍾澤裕; 陳怡菁; 林南海; | 書刊名 | 長庚醫誌 |
卷 期 | 33:2 2010.03-04[民99.03-04] |
頁 次 | 頁126-136 |
分類號 | 414.33 |
關鍵詞 | 強心配醣體; 人參皂苷; 丹參酚酸B鎂鹽; 鈉鉀幫浦; 活血化瘀; Cardiac glycoside; Ginsenoside; Magnesium lithospermate B; Na⁺, K⁺-ATPase; Promoting blood circulation; |
語 文 | 英文(English) |
中文摘要 | C-3 C-6 C-20 B B 3D |
英文摘要 | The therapeutic effect of cardiac glycosides for congestive heart failure lies in their reversible inhibition on Na+, K+- ATPase located in human myocardium. Several steroid-like compounds containing a core structure similar to cardiac glycosides have been found in many Chinese herbs and medicinal animal products conventionally used to promote blood circulation. They are putatively responsible for the therapeutic effect of those medicinal products via the same mechanism of inhibiting Na+, K+-ATPase. Inhibitory potency on Na+, K+- ATPase by ginsenosides, one of the identified steroid-like compounds, is significantly affected by sugar attachment that might cause steric hindrance of their binding to Na+, K+- ATPase. Ginsenosides with sugar moieties attached only to the C-3 position of the steroid-like structure, equivalent to the sugar position in cardiac glycosides, substantially inhibit Na+, K+-ATPase. However, their inhibitory potency is abolished when sugar moieties are linked to the C-6 or C-20 position of the steroid-like structure. In contrast, no appreciable contents of steroid-like compounds are found in danshen, a well-known Chinese herb traditionally regarded as an effective medicine promoting blood circulation. Instead, magnesium lithospermate B (MLB), the major soluble ingredient in danshen, is assumed to be responsible for the therapeutic effect by inhibiting Na+, K+-ATPase in a manner comparable to cardiac glycosides. Neuroprotective effects of cardiac glycosides, ginsenosides and MLB against ischemic stroke were accordingly observed in a cortical brain slice-based assay model. Whether the neuroprotection is also triggered by inhibition of Na+, K+-ATPase remains to be investigated. Molecular modeling suggests that cardiac glycosides, ginsenosides and MLB presumably bind to the same extracellular pocket of the Na+, K+-ATPase α subunit. |
本系統中英文摘要資訊取自各篇刊載內容。