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題 名 | Rosuvastatin-Induced Thrombocytopenic Purpura--A Case Report=Rosuvastatin誘發血小板減少性紫斑症--病例報告 |
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作 者 | 林政緯; 何信君; 楊志勛; 許仲瑤; 鐘文宏; | 書刊名 | 中華皮膚科醫學雜誌 |
卷 期 | 27:4 2009.12[民98.12] |
頁 次 | 頁235-240 |
分類號 | 415.62 |
關鍵詞 | 血小板減少性紫斑症; 降血脂藥; Rosuvastatin; Idiopathic thrombocytopenic purpura; Thrombotic thrombocytopenic purpura; Low-density lipoprotein; High-density lipoprotein; |
語 文 | 英文(English) |
英文摘要 | Many medications can cause thrombocytopenic purpura, including some hypolipidemic agents. This is the fi rst case report of thrombocytopenic purpura due to the 3-hydroxy-3-methylglutaryl- coenzyme A reductase inhibitor, rosuvastatin. A 57-year-old Asian man developed multiple petechiae and purpura one month after receiving rosuvastatin in a dosage of 20 mg/day. When the drug was stopped and the patient was treated with systemic methylprednisolone, 24 mg/day, his symptoms cleared within 4 weeks. The symptoms may have been due to an immunemediated reaction. Also, since statins can alter antiplatelet and antithrombotic properties through significant inhibition of the activated platelet thrombin receptor (Proteinase-Activated Receptor- 1), an overwhelming inhibition of platelet thrombin receptors might also have caused the thrombocytopenia. Because rosuvastatin is used throughout the world to treat hyperlipidemia, and Asian patients have a twofold higher systemic exposure than do Caucasian patients, physicians should be familiar with its possible adverse effects, and use with caution when determining the starting dose, especially among Asian patients |
本系統中英文摘要資訊取自各篇刊載內容。