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題名 | The Functional Role of Glycogen Synthase Kinase-3 in Cell=肝醣合成酶激酶-3在細胞中所扮演的功能性角色 |
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作者 | 蔡明明; 黃子豪; 蔡青青; 黃文忠; 劉倩君; | 書刊名 | 長庚科技學刊 |
卷期 | 10 2009.06[民98.06] |
頁次 | 頁83-102 |
分類號 | 368.6 |
關鍵詞 | 肝醣合成酶激酶-3; Wnt蛋白質; 訊息傳導; 胚胎分化; 細胞增生; 細胞凋亡; 癌化; 轉錄因子; Glycogen synthase kinase-3; Wnt proteins; Signal transduction; Embryogenesis; Cell proliferation; Apoptosis; Transcription factors; |
語文 | 英文(English) |
中文摘要 | 肝醣合成酶激酶-3(Glycogen synthase kinase 3; GSK-3)是存在於所有的真核細胞中的一種serine/theronine激酶(Kinase)。此酵素不但能夠促使肝醣合成酶(glycogen synthase)磷酸化及抑制肝醣的合成,並且可以藉由磷酸化調控許多重要蛋白質的功能。本文回顧近年來的文獻,闡述GSK-3如何影響訊息傳導的途徑,胚胎的分化,細胞的增生,細胞凋亡,及癌化。此外,也一併討論GSK-3基因缺失的影響,GSK-3a and GSK-3b在功能上可能的差異,以及目前以GSK-3為標的,在發展藥物上的進展。本篇文章將有助於對GSK-3的重要性有更進一步的了解。 |
英文摘要 | Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase that is present in all eukaryotic cells. This enzyme phosphorylates not only glycogen synthase to suppress enzyme activity and glycogen synthesis, but also a wide range of proteins in cells, modulating their functions. This article elucidates the mechanism by which phosphorylation by GSK-3 influences signaling pathways, embryogenesis, cell proliferation, apoptosis, oncogenesis, and the functions of transcription factors. The effects of genetic defects on the GSK-3 gene, functional differences between GSK-3 and GSK-3 and the recent advances on drug development, using GSK-3 as a drug target, are discussed. This article offers useful information about the importance of GSK-3. |
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