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題名 | Application of Allele-Specific Polymerase Chain Reaction for Rapid Differentiation of Mycobacterium Leprae from Mycobacterium Tuberculosis=使用對偶基因特異性聚合酶連鎖反應快速辨別麻風分枝桿菌及結核分枝桿菌感染 |
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作者姓名(中文) | 顏育達; 鄭裕文; 吳唯銘; | 書刊名 | 中華皮膚科醫學雜誌 |
卷期 | 27:3 2009.09[民98.09] |
頁次 | 頁170-175 |
分類號 | 415.2776 |
關鍵詞 | 麻風分枝桿菌; 結核分枝桿菌; 對偶基因特異性聚合酶連鎖反應; Allele-specific PCR; Leprosy; Lupus vulgaris; |
語文 | 英文(English) |
英文摘要 | Leprosy (Hansen’s disease) is a chronic granulomatous infection caused by Mycobacterium leprae affecting primarily skin and nerves. Leprosy is an important clinical problem and is also a challenging diagnostic problem for clinicians. Clinically, leprosy might at times be diffi cult to be distinguished from lupus vulgaris. We report a 70-year-old woman who showed a well-demarcated erythematous enlarging plaque on left peri-ocular region suggesting leprosy resembling lupus vulgaris. Skin biopsy was performed and mycobacterial infection was identifi ed. However, it was uncertain to differentiate between tuberculosis and leprosy. To solve the problem, we design an allele-specifi c polymerase chain reaction based on two-nucleotide difference between bacilli of TB and leprosy. Our result showed allele-specifi c polymerase chain reaction can rapidly differentiate the infection caused by M leprae or by M tuberculosis. |
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