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題 名 | Intravenous Thrombolytic Therapy for Acute Ischemic Stroke: The Experience of a Community Hospital=靜脈血栓溶解劑治療急性缺血性腦中風:區域醫院之經驗 |
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作 者 | 許永居; 宋昇峰; 翁埈德; 吳啟順; 蘇裕翔; | 書刊名 | Acta Neurologica Taiwanica |
卷 期 | 18:1 2009.03[民98.03] |
頁 次 | 頁14-20 |
分類號 | 415.922 |
關鍵詞 | 靜脈血栓溶解劑; 腦中風; Ischemic stroke; Thrombolytic therapy; Tissue plasminogen activator; |
語 文 | 英文(English) |
英文摘要 | Background and Purpose: Tissue plasminogen activator (tPA) is a standard therapy for acute ischemic stroke (AIS) but only limited data are noted in Taiwan. The purpose of this study was to assess the safety, feasibility, and efficacy of treatment in a community hospital setting. Methods: We retrospectively reviewed the medical records of all patients who had received intravenous tPA therapy from 1998 to 2007 in our hospital. We compared thea characteristics, complications, and outcomes in our patients with those of patients in the National Institute of Neurological Disorders and Stroke (NINDS) trial. Results: A total of 43 patients were reviewed with a mean age of 63 years and a male predominane (64%). The median pretreatment National Institutes of Health Stroke Scale score was 18. In our patients, cardioembolism was the leading course of the strokes. The mean time from stroke onset to treatment was 134 minutes, and the mean door-to-computed tomography-time was 34 minutes while the mean door-to-needle time was 93 minutes. Within 36 hours symptomatic intracerebral hemorrhage occurred in two patients (4.7%). Four patients (9.3%) developed brain herniation with fatality. At follow-up, fourteen patients (33%) had a favorable outcome on the modified Rankin Scale (0-1). Patient outcome was not significantly different from that in the NINDS trial. Conclusion: Although the number of patients with AIS receiving tPA in this study was small, thrombolytic therapy can be performed safely and effectively by physicians in the community hospital setting. |
本系統中英文摘要資訊取自各篇刊載內容。