頁籤選單縮合
題名 | 兒童臍帶血移植=Umbilical Cord Blood Transplantation in Children |
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作者姓名(中文) | 江東和; 溫玉娟; | 書刊名 | 腫瘤護理雜誌 |
卷期 | 7:1 2007.06[民96.06] |
頁次 | 頁1-9 |
分類號 | 417.653 |
關鍵詞 | 異體造血幹細胞移植; 移植物抗宿主疾病; 臍帶血移植; Allogeneic stem cell transplantation; Graft-versus-host disease; Umbilical cord blood transplantation; |
語文 | 中文(Chinese) |
中文摘要 | 異體造血幹細胞移植雖然可以治癒血液惡性及非惡性腫瘤疾病之病患,但是即使兄弟姐妹間還是不易找到人類白血球抗原(HLA)相合之捐贈者。再者移植物抗宿主疾病相對毒性的限制因素,也加速醫學界研究以臍帶血以代替骨髓及週邊血液幹細胞移植之來源。臍帶血獨一無二的免疫特性,有利於減少移植物抗宿主疾病的風險。再者,臍帶血可以提供造血幹細胞快速便捷的來源,明顯地增加了可供搜尋幹細胞捐贈者的容易度。此文綜述有關以臍帶血爲捐贈來源的優缺點,並概述臍帶血移植目前的狀況特別在兒科的臨床應用,及如何運用臍帶血移植增加恢復造血功能之策略評析。 |
英文摘要 | Allogeneic stem cell transplantation is one of the curative treatments for patients with hematologic malignancies and nonmalignant disorders. Unfortunately, the majority of patients hardly find a matching sibling donor who supposedly is human leukocyte antigen compatible. Limiting factors such as graft-versus-host disease (GVHD) toxicity have led in to the explorative study of umbilical cord blood (UCB) as an alternative source of hematopoietic stem cells. The unique immunologic properties of UCB likely minimize the risk of GVHD. Thus, UCB provides a highly convenient hematopoietic stem cells source that may significantly expand the HSC donor pool. This overview study considers the advantages and disadvantages of UCB as a donor source and outlines the current status of UCB transplantation, with emphasis herein on pediatric clinical practice. Strategies to improve kinetics of hematopoietic recovery after UCB grafting in children and adults are disucssed. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。