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題 名 | 自主神經失調與心率變異度應用於慢性阻塞性肺疾病患之概念介紹=The Application of Heart Rate Variability in COPD Patients Autonomic Dysregultion |
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作 者 | 饒文琴; 林鴻銓; 盛德芳; 陳麗妃; 何淑娟; | 書刊名 | 呼吸治療雜誌 |
卷 期 | 8:1 2009.01[民98.01] |
頁 次 | 頁43-49 |
分類號 | 415.428 |
關鍵詞 | 心率變異度; 自主神經失調; 慢性阻塞性肺疾病; Heart rate variability; Autonomic dysfunction; COPD; |
語 文 | 中文(Chinese) |
中文摘要 | 自主神經系統與許多器官之功能有關。臨床上慢性阻塞性肺疾(COPD)常因自主神經系統之M2接受器功能失調,易導致支氣管收縮、分泌物增加。心率變異度(Heart rate variability)是代表著自主神經活性的指標,過去提及最多的是心臟方面的影響,然而少有研究將心率變異應用到呼吸系統疾病上,直至2001年起才開始注意到心率變異與胸腔科病患有著密切的關係。近年研究證實測量心率變異度可了解慢性肺阻塞性肺疾病患於缺氧時造成自主神經系統不平衡之間的影響、也得知約有60-70%的重度慢性肺阻塞性肺疾病患有自主神經病變等等。因此本文著重於自主神經對呼吸系統的影響,進而藉由測量分析心率變異度在慢性阻塞性肺病病患的臨床應用,希望增進大家對心率變異度在胸腔科病患評估或治療上的認識與瞭解。 |
英文摘要 | The autonomic nervous system (ANS) is known to be associated with the function of many organ systems. In respiratory system, the ANS is involved in bronchoconstriction and airway mucus secretion in M2 (muscarinic receptor 2) dysfunctional COPD patients. Power spectrum analysis of heart rate variability (HRV) is a noninvasive and reliable method for assessing autonomic function that has been used extensively in the clinical setting. Disruption of autonomic reflexes has been shown to be major risk factors for cardiac morbidity and mortality. Unlike cardiac autonomic balance, the occurrence of autonomic dysfunction and the clinical application of HRV have received much less attention in COPD. Recently, autonomic neuropathy has been reported in chronically hypoxaemic patients of COPD. Based on the survey of HVR, it is also known that about 60-70% severe COPD patients has autonomic dysfunction. This article reviewed the impact of the ANS on respiratory system and the role of HRV assessment to noninvasively evaluate autonomic modulation in patients with COPD. By the understanding of the important role of autonomic nervous dysfunction in respiratory diseases, our article, therefore, provides the challenges and opportunities in developing therapeutic strategies. |
本系統中英文摘要資訊取自各篇刊載內容。