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題名 | 全靜脈營養輸液添加精胺酸及N□-Monomethyl-L-Arginine對腹膜炎大鼠免疫反應之影響=Effects of Arginine and N□-Monomethyl-L-Arginine-Supplemented Total Parenteral Nutrition |
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作者 | 陳靜儀; 羅慧珍; 鄭君祥; 蔡麗卿; | 書刊名 | 臺灣營養學會雜誌 |
卷期 | 33:2 2008.06[民97.06] |
頁次 | 頁66-76 |
分類號 | 416.351 |
關鍵詞 | 精胺酸; 一氧化氮合成酶抑制劑; 腹膜炎; 淋巴細胞分佈; 細胞激素; Arginine; L-NMMA; Peritonitis; Lymphocyte subsets; Cytokine; |
語文 | 中文(Chinese) |
中文摘要 | 研究指出精胺酸(arginine)具有促進蛋白質合成及調節免疫的作用,但感染時arginine經一氧化氮合成?(NOS)作用大量產生一氧化氮時,易引發敗血症。先前的實驗證實,以靜脈給予arginine可減緩腹膜炎大鼠的發炎反應,但同時給予arginine及NOS抑制劑(L-NMMA)未變善其高度代謝及發炎現象。本實驗進一步探討arginine及L-NMMA對腹膜炎大鼠免疫反應的影響。雄性Wistar大鼠以盲腸穿孔手術誘發腹膜炎及經頸靜脈插管後,給予傳統全靜脈營養輸液或添加arginine、L-NMMA、或arginine與L-NMMA的全靜脈營養輸液。另包括未誘發腹膜炎且給予傳統全靜脈營養輸液的對照組。實驗進行三天後收集血液、脾臟及胸腺進行免疫分析。結果顯示,靜脈給予arginine顯著降低腹膜炎大鼠脾臟重量、血清間白素(IL)-6、與白血球、脾臟巨噬細胞及胸腺細胞IL-6分泌量,且顯著降低白血球與胸腺細胞腫瘤壞死因子(TNF)-α分泌量,但顯著增加胸腺T細胞增生的刺激指數。單獨給予L-NMMA及同時給予arginine和L-NMMA,顯著降低白血球TNF-α與胸腺細胞TNF-α及IL-6分泌量。此外,同時給予arginine和L-NMMA顯著增加脾臟巨噬細胞TNF-α及胸腺細胞IL-2分泌量,且顯著增加脾臟CD45RA+、CD45RA+IgM+及CD11b/c+數目。綜合以上結果顯示,靜脈給予arginine具有改善腹膜炎脾臟腫大、刺激胸腺細胞增生、與降低血液、脾臟及胸腺分泌發炎媒介物的作用,若同時給予arginine及L-NMMA則進一步增加脾臟巨噬細胞的數目及功能。 |
英文摘要 | Evidence indicates that arginine may stimulate protein synthesis and modulate immune function. However, during infection, nitric oxide synthase (NOS) catalyzes arginine to produce excess nitric oxide that results in sepsis. We previously demonstrated that intravenously administered arginine attenuates the inflammatory response, whereas the simultaneous administration of arginine and an NOS inhibitor, i.e., L-NMMA, might not improve hypermetabolic and inflammatory response in peritonitic rats. Therefore, we further investigated the effects of arginine and L-NMMA on immune responses. Male Wistar rats, which underwent cecal puncture and jugular vein cannulation, were administered with a conentiona, or arginine-, L-NMMA-, or arginine plus L-NMMA-supplemented parenteral nutrition solution. Non-peritonitic rats infused with the conventional parenteral nutrition solution were included as the control[?]. Three days later, circulating leukocytes, splenocytes, and thymocytes were collected for immune analysis. We found that intravenously administered arginine significantly decreased the spleen weight, the serum interleukin (IL)-6 level, and IL-6 production by leukocytes, splenic macrophages, and thymoctyes; significantly decreased tumor-necrosis factor (TNF)-α production of leukocytes and thymocytes; and significantly increased the stimulating index of cell proliferation in T-thymocytes in peritonitic rats. L-NMMA with or without arginine significantly decreased TNF-α production by leukocytes and TNF-α and IL-6 production by thymocytes. Furthermore, arginine plus L-NMMA significantly increased TNF-c production by splenocytic macrophages, IL-2 produciton in T-thymocytes, and the numbers of CD46RA+, CD45RA+IgM+, and CD11b/c+ in the spleen. In summary, intravenous administration of arginine may improve splenic hypertrophy, stimulate thymocytic proliferation, the simultaneous administration of arginine and L-NMMA further increased the number and functions of splenic macrophages. |
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