頁籤選單縮合
題 名 | Isolation and Identification of Three Thio-sildenafil Analogues in Dietary Supplements=保健食品中三種含威而鋼類緣物之純化與鑑定 |
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作 者 | 賴國誌; 劉宜祝; 廖永智; 林雲蓮; 蔡麗瑤; 林哲輝; 羅吉方; | 書刊名 | Journal of Food and Drug Analysis |
卷 期 | 18:4 2010.08[民99.08] |
頁 次 | 頁269-278 |
分類號 | 412.37 |
關鍵詞 | 核磁共振儀; Thiosildenafil; Thiohomosildenafil; Hydroxythiohomosildenafil; NMR; |
語 文 | 英文(English) |
英文摘要 | ABSTRACT Three compounds were found to have been illegally added to dietary supplements marketed for erectile dysfunction. The structures of these compounds were identified with NMR, HRMS, IR, UV and LC/MS/MS, after comparison with the structure of sildenafil, data showed that the oxygen atom of the carbonyl group in the heterocyclic ring had been replaced with a sulfur atom, these thio-sildenafil analogues were identified as thiosildenafil, thiohomosildenafil and hydroxythiohomosildenafil. Since their structures were similar to that of sildenafil, according to structure-activity relationship, the side effects of these analogues might also associate with that of sildenafil. In accordance with this finding, thio-sildenafil analogues have been included in the inspection list of illegal adulterants in Taiwan. From January to October 2009, thiosildenafil was detected in 6 samples, thiohomosildenafil was detected in 4 samples and hydroxythiohomosildenafil was detected in 3 samples. |
本系統中英文摘要資訊取自各篇刊載內容。