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題 名 | A Water Extract of Pueraria Lobata Inhibited Cytotoxicity of Enterovirus 71 in a Human Foreskin Fibroblast Cell Line=葛根(Pueraria Lobata)熱水萃取物在人類包皮纖維母細胞株抑制腸病毒71型造成的細胞毒性 |
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作 者 | 蘇富敏; 張榮參; 王國治; 蔡季君; 蔣連財; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 24:10 2008.10[民97.10] |
頁 次 | 頁523-530 |
分類號 | 418.11 |
關鍵詞 | 化學預防; 腸病毒; 腸病毒71型; 葛根; 治療; Chemoprevention; Enterovirus; EV71; Pueraria lobata; Therapy; |
語 文 | 英文(English) |
中文摘要 | 腸病毒 71 型 (EV71) 可導致腦性腦炎和死亡。但是目前並無有效的疫苗,也沒有化療藥物可用於治療腸病毒 71 型造成的感染。我們利用人類包皮纖維母細胞株以及 XTT 方法檢定葛根熱水萃取物能有效抑制腸病毒 71 型的細胞毒性作用。我們的結果顯示,葛根熱水萃取物能有效抑制腸病毒 71 型感染產生的細胞毒性作用。在病毒感染前投與 (p < 0.0001),在病毒感染時投與 (p < 0.0001),或在病毒感染之後投與 (p < 0.0001),皆能顯示葛根熱水萃取物有效抑制腸病毒 71 型感染造成的細胞毒殺作用。本實驗證實葛根熱水萃取物抑制腸病毒 71 型是有效 (IC50 為0.028 microg/mL) 而且安全 ( 選擇指數大於 107000)。葛根可能可以抑制病毒附著 (p < 0.0001) 和穿透 (p < 0.0001) 細胞的過程。葛根熱水萃取物不會增加腸病毒 71 型感染產生的干擾素,因此其作用機轉和干擾素無關。結論為葛根熱水萃取物將來可能可用於腸病毒 71 型感染的防治。 |
英文摘要 | Enterovirus 71 (EV71) can cause brain encephalitis and mortality. However, effective vaccines or chemotherapeutic agents are not yet available. We tested the hypothesis that Pueraria lobata could inhibit the cytotoxic effect of EV71 in a human foreskin fibroblast cell line by the XTT method. Our results showed that the water extract of P. lobata could inhibit cytopathy induced by EV71 when given before (p < 0.0001), simultaneously with (p < 0.0001), or after viral infection (p < 0.0001). Water extract of P. lobata was effective and its minimal concentration that inhibited 50% of the cytopathic effect (IC50) was 0.028 microg/mL. P. lobata was also safe with a selectivity index greater than 107,000. Water extract of P. lobata appeared to inhibit viral attachment (p < 0.0001) and penetration (p < 0.0001). The anti-EV71 activity of the water extract of P. lobata was not mediated by interferons. In conclusion, the water extract of P. lobata was effective in the management of the disease induced by EV71 infection. |
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