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頁籤選單縮合
題 名 | Eicosanoids in Asthma=Eicosanoids在氣喘所扮演的角色 |
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作 者 | 吳港生; 吳維峯; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷 期 | 48:6 2007.11-12[民96.11-12] |
頁 次 | 頁299-304 |
分類號 | 415.425 |
關鍵詞 | 氣喘; Eicosanoid; Cysteynil leukotreine; Lipoxin; Prostaglandin; Asthma; |
語 文 | 英文(English) |
英文摘要 | Ficosanoids belong to a diverse family of bioactive fatty acids that play important roles in regulating airway inflammation and reactivity. They are the key mediators of the pathobiology of asthma. Among the eicosanoids, lipoxins (LXs) were the first agents to be identified and recognized as potential anti-inflammatory endogenous lipid mediators. Lipoxins are biosynthesized in vivo at inflammation sites. They result mainly from the interaction between 5 and 15-lipoxygenases (LOs), which are distinct from leukotrienes (LTs) and prostaglandins (FGs) in structure and function. Leukotrienes are potent pro inflammatory mediators and directly and indirectly stimulate fibro blast chemot axis, proliferation, and collagen synthesis. Frostaglandins have both bronchoconstrictive and bronchoprotective effects and the bronchoconstriction mediated by FGD2 and FGF2e is only occurred in asthmatic patients but not in healthy subjects. Lipoxins counter-regulate the proinflammatory actions of LTs and activate resolution of the inflammatory response. At least two classes of receptors, CysLTJ receptors and Asprin-triggered lipoxin A4 (ALX) receptors, can interact with lipoxin A4 (LXA4) and LXA4 analogs to mediate their biologic actions. Allergen challenge initiates airway biosynthesis of 1)644 and increases expression of its receptor. In addition, LXA4 affects the releace of interleukin-8 by blood mononuclear cells, and ALX affects calcium influx into epithelial cells. Therefore, the pivotal role of LXs is mediating airway homeostasis, and LXs may be part of a novel, multipronged approach for treating human asthma. |
本系統中英文摘要資訊取自各篇刊載內容。