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| 題 名 | Resistance of Mycobacterium Tuberculosis to Four First-line Anti-tuberculosis Drugs in a Referral Hospital in Northern Taiwan, 2002-2006=北臺灣某後送醫院之四種第一線抗結核藥物抗藥性研究,2002-2006 |
|---|---|
| 作 者 | 林賢君; 余芳蘭; 李兆清; 白冠壬; 李俊年; 許翰琳; 余明治; | 書刊名 | 胸腔醫學 |
| 卷 期 | 23:5 2008.10[民97.10] |
| 頁 次 | 頁316-324 |
| 分類號 | 418.284 |
| 關鍵詞 | 抗藥性; 結核菌; Drug resistance; Mycobacterium tuberculosis; |
| 語 文 | 英文(English) |
| 中文摘要 | 前言:探討2002至2006年,台北醫學大學˙萬芳醫院的結核菌對第一線抗結核菌藥物 (isoniazid、rifampin、ethambutol及streptomycin) 抗藥性情況。 方法:以回溯性方法來調查。從2002年1月至2006年12月,436株接受藥物敏感試驗之結核菌株被分析。藥物敏感試驗使用間接瓊脂比例法 (indirect agar proportion method)。 結果:436株結核菌株中,343株來自於新病人,93株來自於曾經治療過的病人。全部菌株中,至少對一種抗結核菌藥物具抗藥性的比率為17.6%。新病人與曾經治療過病人中,至少對一種抗結核菌藥物具抗藥性的比率分別為11.7%與39.8%。全部菌株中,對個別抗結核菌藥物具抗藥性的比率分別為:isoniazid12.4%、rifampin 7.1%、ethambutol 3.2%、streptomycin 9.2%。多重抗藥性 (至少對isoniazid與rifampin具抗藥性) 發生於全部病人、新病人、曾經治療過病人的比率分別為:5.7%、1.5%、21.5%。 結論:在臺灣,抗藥性的存在對治療結核病仍然是一嚴重問題。因此,在治療結核病時,特別對曾經使用過藥物的病人,應該要考慮到抗藥性問題。 |
| 英文摘要 | Introduction: The purpose of this retrospective study was to investigate the drug resistance of Mycobacterium tuberculosis to 4 first-line anti-tuberculosis (TB) drugs (isoniazid (INH), rifampin (RIF), ethambutol (EMB), streptomycin (SM)) at Taipei Medical University-Wan Fang Hospital from 2002 to 2006. Methods: From 1 January 2002 through 31 December 2006, drug susceptibility testing for first-line anti-TB drugs, including INH, RIF, EMB, and SM, was performed using the indirect agar proportion method. A retrospective review of medical records to define the drug resistance of new, previously treated, and combined cases was conducted. Results: Of the 436 M. tuberculosis isolates, 343 were recovered from new cases and 93 from previously treated cases. The combined drug resistance rate to at least 1 drug was 17.6%. The drug resistance rate to at least 1 drug among new cases was 11.7% and among previously treated cases was 39.8%. The combined drug resistance rate to individual drugs was 12.4% to INH, 7.1% to RIF, 3.2% to EMB, and 9.2% to SM. The rates of combined multidrug resistance (resistance to at least INH and RIF), among new cases, and previously treated cases were 5.7%, 1.5%, and 21.5%, respectively. Conclusions: Drug resistance remains a serious problem in the treatment of TB in Taiwan. When treating a TB patient, drug resistance should be considered, especially in previously treated cases. |
本系統中英文摘要資訊取自各篇刊載內容。