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題名 | 細胞外基質金屬蛋白酶的表現與肺纖維化=Matrix Metalloproteinases and Lung Fibrosis |
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作者 | 周佳正; 馮南雄; 林恆毅; 李菊芬; 賴志堅; Chou, Chia-cheng; Feng, Nang-hsiung; Lin, Hen-i; Lee, Jyu-feng; Lai, Chi-jan; |
期刊 | 輔仁醫學期刊 |
出版日期 | 20061200 |
卷期 | 4:4(幹細胞與肺纖維化專刊) 民95.12 |
頁次 | 頁S57-S67 |
分類號 | 415.46 |
語文 | chi |
關鍵詞 | 肺纖維化; 抗癌用葯; 基質金屬蛋白酶; Matrix metalloproteinases; Lung fibrosis; Bleomycin; |
中文摘要 | 肺纖維化至目前為止仍是臨床上一棘手問題。它可能起始於肺部發炎反應, 進一步透過氧游離基、細胞素、生長因子的作用造成肺組織內各種細胞外基質的金屬蛋白與金屬蛋白抑制劑的分佈失衡,造成過量的膠原蛋白堆積在肺組織,以致於肺順應性改變、肺容積明顯變小,呼吸困難,呼吸衰竭等臨床症狀。本評論先對抗癌用葯Bleomycin 引起肺部組織的纖維化作一簡介,然後再環繞在胞外基質蛋白表現與肺纖維化發生的關係作一簡要的描述。 |
英文摘要 | Currently, lung fibrosis is still a difficult clinical problem. It caninitially occur due to lung inflammation then be further exacerbated by the reaction of oxygenradicals, cytokines, and growth factors to induce an imbalance between matrix extracellularmetalloproteinases (MMPs) and their inhibitors, tissue inhibitors of matrix metalloproteinases(TIMPs) . This causes excess collagen proteins to accumulate in lung tissues, inducing clinicalsymptoms such as lung compliance changes, lung volume decreases, dyspnea, and respiratory failure.In this comment we focus on the induction of lung fibrosis by bleomycin, an anticancer drug.Furthermore, we correlate lung fibrosis with MMP expressions. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。