頁籤選單縮合
| 題 名 | Molecular Epidemiology of Dengue Virus Serotype 2 in the Taiwan 2002 Outbreak with Envelope Gene and Nonstructural Protein 1 Gene Analysis=分析Envelope與Nonstructural Protein 1基因以探討2002年臺灣第二型登革熱群突發之分子流行病學 |
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| 作 者 | 董宜青; 林貴香; 江宏哲; 柯良胤; 陳彥旭; 柯冠銘; 陳惇杰; 周麗秋; 盧柏樑; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
| 卷 期 | 24:8 2008.08[民97.08] |
| 頁 次 | 頁398-407 |
| 分類號 | 415.239 |
| 關鍵詞 | 第二型登革熱病毒; Envelope基因; Nonstructural protein 1基因; Dengue virus serotype 2; Envelope gene; Nonstructural protein 1 gene; |
| 語 文 | 英文(English) |
| 中文摘要 | 由 envelope (E) 與 nonstructural protein 1 (NS1) 基因分析 2002 年台灣第二型登革熱群突發發現十株病毒株之間只有 0-0.4% 之差異,顯示該群突發為一流行病毒株之傳播。親源關係分析顯示 2002 年台灣第二型登革熱病毒為 Cosmopolitan 基因型,不同於 1981 至 1998 的 Asian 1 與 Asian 2 基因型以及 2005 年的 American/Asian 基因型。雖然以 E 基因和 NS1 基因分析對病毒株之分群可得到一致的結果,NS1 基因用於第二型登革熱病毒親源關係分析的效度因其較低之 bootstrap 數值而未能在本研究中獲得證實。研究發現台灣與菲律賓之第二型登革熱之主要基因型至 2002 年都同樣有由 Asian 2 基因型改變為以 Cosmopolitan 基因型為主,顯示病毒株的傳播可能導致臨近國家有相同基因型改變之趨勢 |
| 英文摘要 | The genetic relationships among dengue virus serotype 2 (DEN-2) isolates from the Taiwan 2002 epidemic were studied by sequence analysis of the envelope (E) and nonstructural protein 1 (NS1) genes. A 0-0.4% divergence among 10 isolates revealed an epidemic strain in the outbreak. Phylogenetic study demonstrated that the 2002 Taiwan isolates were of the Cosmopolitan genotype, which is different from the Asian 1 and Asian 2 genotypes of Taiwan DEN-2 isolates from 1981 to 1998 and the American/Asian genotype of 2005 Taiwan isolates. Although grouping results from both E and NS1 gene sequence analyses were the same, the usage of the NS1 gene as a sequence analysis target has not been validated for the lower bootstrap support values of branches in the phylogenetic tree. Our result showing the same genotype changes in Taiwan and Philippines isolates suggests strain transfer of DEN-2 to nearby countries resulting in the same trend of genotype change. |
本系統中英文摘要資訊取自各篇刊載內容。