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題 名 | 性功能障礙治療藥物的現況=Current Medical Treatment for Sexual Dysfunctions |
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作 者 | 李易軒; | 書刊名 | 澄清醫護管理雜誌 |
卷 期 | 4:4 2008.10[民97.10] |
頁 次 | 頁37-44 |
分類號 | 418.27 |
關鍵詞 | 威而剛; 快威猛; 樂威壯; 犀利士; 磷酸二脂酶; 陽痿; Viagra®; Leritra®; Cialis®; Uprima®; Phospodiesterase; Impotence; |
語 文 | 中文(Chinese) |
中文摘要 | 性功能障礙的定義為無法達到且維持足夠令 人滿意的性交過程。當性刺激發生時會釋放一氧 化氮進入陰莖的平滑肌中,此時抑制第五型的磷 酸(二脂時可以提升龜頭、陰莖海綿體中的cGMP 濃度,進而增加平滑肌的放鬆與勃起的完整度。 有勃起困難的病忠常會併有潛在性的心臟病變, 在使用第五型磷酸二脂時抑制劑,尤其與硝酸鹽 併用時會導致嚴重的低血壓及多種嚴重的心血管 副作用。另外,第五型磷酸二脂時抑制劑也會因 部分抑制到第六型磷酸二脂時而導致眼睛的副作 用。 性功能障礙 廣義來說,性功能障礙可以是器質性的功 能不全,也可以是性慾缺乏。而勃起功能障礙 (erectile dysfunction) ,過去被稱之為性無能或 是陽瘦,指的是男性性器官暫時或持續的無法產 生或維持適當的勃起狀態,而使性的雙方都感覺 不到滿意。 從用來治療巴金森氏症的老藥Uprima目前因 為可以提昇性慾且可以讓不能使用硝酸鹽類的病 息受息而被用來治療勃起障礙。Uprima不同於其 他的PDE5抑制劑直接作用,而是從下丘腦直接增 加訊號的可專遞。 陽屢治療劑的發展過程Sildenafil citrate (Viagra@)這個成分早在1986 年已被發現。由一位法國醫師RonaldVirag在一 次手術中,不小心將含氮的藥物注射到病患的 陰莖海綿體內,導致病患整整勃起達兩個小時, 讓外科對勃起有了新的瞭解。1991年時,輝瑞大 藥廠使用代號UK-92480的實驗藥物在抑制PDE3 (phosphodiesterase type 3)來治療狹心症的臨 床試驗,卻結果效果不理想而中止實驗。然而臨 床病人用盡各種藉口,不肯交回剩餘的藥品。 之後輝瑞大藥廠的研究人員發現原來這個藥物 對於PDE5的選擇性較高,可以使陽瘦患者的陰 莖勃起。自此,UK-92480正式定名為Sildenafil citrate '研究對象也改為有勃起功能障礙(陽瘦)的 病人。 Aprostadil則比成而剛更早作為勃起困難的治 療劑但卻因為不方便使用而退為後線療法。 Intrinsa則經皮穿透貼片是針對雙測卵巢切除 及子宮切除後停經且併用雌性素療法的女性的性 慾低落症所設計的藥物。 性功能障礙的治療不能只依賴藥物,且更需 要伴侶之間的良性溝通與積捶互動。 |
英文摘要 | Pharmacy Department ,Chung-KangBranch,Cheng Ching Hospital Erectile dysfunction (ED) is defined as the inability to achieve and maintain an erection in order to perform satisfactory sexual intercourse. When sexual stimulation releases nitric oxide into the penile smooth muscle, inhibition of phosphodiesterase type 5 (PDE 5) causes a marked elevation ofcyclic guanosine monophosphate (cGMP) concentrations in the glans penis, corpus cavernosum, and corpus spongiosum. This increases smooth-muscle relaxation and produces an erection. The most popular drugs to treat ED are PDE 5 inhibitors. These include sildenaful viagra), vardenafil (Levita) and tadalafil (Cialis). 。ndiseffective for a longer period of time after ingestion. The cardiovascular adverse side-effects of PDE5 inhibitors are important because Tadalafl has the longest half-life of the equent presence of underlying cardiac disease in men with ED. inhibitors are combined with nitrates, severe cardiac events such as hypotension have When PDE 5 been reported. PDE5 inhibitors which have a partial effect on PDE6 may also cause visual disturbances. Apomorphine (Uprima@), an old drug to treat Parkinson disease, is now used to increase libido in men treated with nitrates. Uprima@ has a different effect from PDE5 inhibitors as it acts upon receptors in the hypothalamus and can enhance erection by increasing the signals from the brain to begin the process. Alprostadil was available for the treatment for ED years before sildenafil (Vzagra@),but the delivery method (intracavernous injection or intraurethral suppository) makes it unpopular as a first line treatment at present. The use of a testosterone (Intrisna)transdermal patch is indicated in the treatment of hypoactive sexual desire disorder (HSDD) in bilaterally oophorectomised and hysterectomised (surgically induced menopausal) women receiving concomitant estrogen therapy. Some studies suggest that sildenafil may also be helpful to these women. There are many drug therapies (including hormone replacement), but these treatments of sex dysfunction require good communication and positive interaction between couples for them to be successful. |
本系統中英文摘要資訊取自各篇刊載內容。