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頁籤選單縮合
題 名 | 非甲狀腺疾病症候群之醫療困境=The Dilemma of Non-Thyroidal Illness Syndrome |
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作 者 | 王惠芳; 林宏達; | 書刊名 | 內科學誌 |
卷 期 | 19:3 2008.06[民97.06] |
頁 次 | 頁213-218 |
分類號 | 415.66 |
關鍵詞 | 非甲狀腺疾病症候群; 三碘甲狀腺素; 逆三碘甲狀腺素; 甲狀腺素; 甲狀腺促素; Non-thyroidal illness syndrome; NTIS; Triiodothyronine; T3; Reverse triiodothyronine; rT3; Thyroxine; T4; Thyrotropin; TSH; |
語 文 | 中文(Chinese) |
中文摘要 | 非甲狀腺疾病症候群 (non-thyroidal illness syndrome,NTIS) 患者之內分泌檢驗數據,依病情嚴重程度而有多樣的變化。初期表現爲血中三碘甲狀腺素濃度偏低,逆三碘甲狀腺素濃度偏高,疾病的持續進一步使血中甲狀腺素濃度下降,疾病嚴重時游離四碘甲狀腺素與甲狀腺促素濃度亦會降低。作用機轉包括周邊相關激素的代謝異常、血液中結合蛋白質濃度的改變、球蛋白與激素結合力下降、下視丘與腦垂體功能失調,以及藥物對腦垂體分泌甲狀腺促素的干擾。病患的甲狀腺功能是否正常,以及是否需要補充激素仍有許多爭議。本文綜述正反雙方不同之意見,並突顯此醫療困境。 |
英文摘要 | Many non-thyroidal disorders accompanied by abnormality of thyroid function tests defined as non-thyroidal illness syndrome (NTIS) are characterized by decreasing for serum triiodothyronine (T3), increasing for serum reverse T3, and, in the most severe pattern, dropping for serum thyroxine. Though thyrotropin usually remains normal, hormone changes in NTIS representing "physiologic" or "pathologic" hypothyroid state is still controversial. Our article tried to discuss the issue whether correcting NTIS with thyroid hormones is beneficial. In addition, we may suggest that prospective, randomized, placebo-controlled studies enrolling a large number of patientsmay provide more evidence in the future. |
本系統中英文摘要資訊取自各篇刊載內容。