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題 名 | Potential Role of Vascular Endothelial Growth Factor, Interleukin-8 and Monocyte Chemoattractant Protein-1 in Periodontal Disease=血管內皮生長因子、介白質-8與單核細胞趨化吸引蛋白-1於牙周病之潛在性角色 |
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作 者 | 李恩; 楊奕馨; 何雅萍; 何坤炎; 蔡吉政; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 19:8 2003.08[民92.08] |
頁 次 | 頁406-415 |
分類號 | 416.946 |
關鍵詞 | Vascular endothelial growth factor; Cytokines; Chemokines; Periodontopathogens; Periodontal disease; 牙齦溝液; 細胞激素; 牙周致病菌; |
語 文 | 英文(English) |
中文摘要 | 由細菌所引起的慢性發炎,常導致由宿主-媒介引發對微生物侵犯附近組織的破壞。研究牙周致病菌與宿主炎性細胞激素,特別是與血管組織的再塑造和增生相關的細胞激素,並不多見。本實驗從 36 位患者(年齡 30-63 歲,平均 43 歲)收集 140 個牙齦下牙菌斑與牙齦溝液樣本,以免疫螢光和暗視野顯微鏡法探討牙齦下牙菌斑中選定之牙周致病菌(B. forsythus、C. rectus、P. gingivalis、P. intermedia) 所佔的比例;牙齦溝液內 vascular endothelial growth factor (VEGF)、monocyte chemoattractant protein-1(MCP-1)和 interleukin-8(IL-8)等細胞激素則用酵素免疫分析法定量分析。結果顯示,牙周炎部位之 VEGF、MCP-1 和 IL-8 總量顯著高於健康部位。進一步分析得知 VEGF 與 IL-8 在濃度與總量上則有高度正相關,牙周致病菌與 VEGF、MCP-1 和 IL-8 之總量亦有正相關。由以上發現,牙周致病菌對與某些特定之炎性細胞激素對導致慢性牙周炎病患牙周組織的破壞確實有一定程度的影響。 |
英文摘要 | Host-mediated immunoinflammatory pathways activated by bacteria lead to destruction of the periodontal connective tissues and alveolar bone. The objective of this study was to elucidate the activation of the inflammatory processes in periodontal disease by quantitative assessment of cytokines and periodontopathogens. Gingival crevicular fluids (GCF) and subgingival plaque samples were collected from patients with chronic periodontitis and gingivitis and from periodontally healthy sites. Vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), and interleukin 8 (IL-8) in GCF were analyzed by enzyme-linked immunosorbent assay. Periodontopathogens, including Bacteroides forsythus, Campylobacter rectus, Porphyromonas gingivalis and Prevotella intermedia, were analyzed by immunofluorescence and dark-field microscopy. There was significantly more VEGF and IL-8 in chronic periodontitis and gingivitis sites than in periodontally healthy sites. There were significant positive correlations between the concentrations and total amounts of VEGF and IL-8 in chronic periodontitis and gingivitis sites, and between the levels of periodontopathogens and the total amounts of VEGF, MCP-1 and IL-8. These data indicate that inflammatory processes induced by periodontopathogens and the activation of certain cytokines (VEGF, MCP-1, IL-8) in periodontal diseases may be relevant to host-mediated destruction in chronic periodontitis. |
本系統中英文摘要資訊取自各篇刊載內容。