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頁籤選單縮合
題名 | Association among Metabolic Syndrome, Testosterone Level and Severity of Erectile Dysfunction=代謝症候群,睪固酮濃度,與勃起功能嚴重度之相關性 |
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作者姓名(中文) | 葉信志; 王起杰; 李永進; 蕭錫麟; 吳文正; 周以和; 黃俊雄; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 24:5 2008.05[民97.05] |
頁次 | 頁240-247 |
分類號 | 415.8616 |
關鍵詞 | 勃起功能障礙; 代謝症候群; 睪固酮; Erectile dysfunction; Metabolic syndrome; Testosterone; |
語文 | 英文(English) |
中文摘要 | 本文的目的在探討代謝症候群與血中睪固酮濃度在勃起功能障礙患者所造成的影響與彼此之間的相關性。我們收集了103 位病人,利用國際勃起功能指標來評估病人的勃起功能。代謝症候群則是根據 2001 年美國國家膽固醇教育計畫所提出的成人治療小組第三版及 2005 年國際糖尿病聯盟的修正版本來定義。病人的平均年齡為 57.5 +/- 10.7 歲,平均的國際勃起功能指標為 14.7 +/- 6.7 分。統計發現年齡以及用成人治療小組第三版定義的代謝症候群在不同嚴重程度勃起功能障礙的族群裡有顯著的不同 p 值分別為 0.031 及 0.009;而使用國際糖尿病聯盟定義的代謝症候群並沒有呈現顯著的差異。在中度/重度勃起功能障礙這一組病人中,高血壓 (78.6% vs. 36.2%;p < 0.001) 與過高的空腹血糖值 (46.4% vs. 19.1%;p = 0.004) 的比例顯著的上升,且進入多變項分析後仍保持顯著的差異 (p 值為 0.001 及 0.042)。血中睪固酮在勃起功能障礙合併有代謝症候群的患者則呈現顯著的下降 (p = 0.002)。總結來說,代謝症候群與較嚴重程度的勃起功能障礙有顯著相關。在代謝症候群的組成中,過高的血壓及空腹血糖值是獨立的危險因子。對於勃起功能障礙的嚴重程度,成人治療小組第三版的定義比國際糖尿病聯盟有較佳的相關性。在有勃起功能障礙的病人中,同時具有代謝症候群的患者其血中睪固酮濃度較低。 |
英文摘要 | The purpose of this study was to determine the influence of metabolic syndrome (MS) and serum testosterone in patients with erectile dysfunction (ED) and their possible association. A total of 103 men with ED were enrolled. The International Index of Erectile Function (IIEF) questionnaire was used to assess erectile condition. MS was defined according to the criteria formulated by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF). The mean age of the study population was 57.5 +/- 10.7 years, with an average IIEF of 14.7 +/- 6.7. The age and prevalence of MS using the NCEP ATP III criteria, but not the IDF criteria, were significantly different between mild and moderate/severe ED patients (p = 0.031 and 0.009, respectively). The percentage of hypertension (78.6% vs. 36.2%; p < 0.001) and raised fasting glucose levels (46.4% vs. 19.1%; p = 0.004) were significantly higher in the moderate/severe ED group, and both differences remained significant in multivariate analysis (p = 0.001 and 0.042, respectively). In addition, serum testosterone levels were significantly lower in ED patients with MS (p = 0.002). In summary, the presence of MS is associated with more severe ED. Among the components of MS, elevated blood pressure and fasting blood glucose were independent risk factors. NCEP ATP III criteria seem to correlate better with the degree of ED than the IDF definition. Our results also indicate that MS is associated with a lower testosterone level in patients with ED. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。