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頁籤選單縮合
題 名 | Phylogenetic Study of Dengue-3 Virus in Taiwan with Sequence Analysis of the Core Gene=分析核心基因以探討臺灣第三型登革熱病毒的親源關係之研究 |
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作 者 | 董宜青; 林貴香; 張科; 柯良胤; 柯冠銘; 盧柏樑; 林俊佑; 陳彥旭; 江宏哲; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 24:2 2008.02[民97.02] |
頁 次 | 頁55-62 |
分類號 | 415.239 |
關鍵詞 | 核心基因; 第三型登革熱病毒; 親源關係分析; Core gene; Dengue-3 virus; Phylogenetic analysis; |
語 文 | 英文(English) |
中文摘要 | 登革熱是一種以蚊子為媒介的全世界最重要之傳染病。目前為止,根據病毒不同基因的親源關係分析,第三型登革熱病毒被分為五個基因型,即第一至第五基因型。為了探討 2005 和 2006 年於南台灣分離的第三型登革熱病毒株基因變異和分子演化的特性,我們分析 12 株病毒之核心基因的 290 個核苷酸序列,並和基因資料庫中各國第三型登革熱病毒株 (包括 4 株 1998 和 1 株 1999 台灣分離株) 做比較。我們發現 2005 和 2006 年病毒株在此段核苷酸序列,有 5.4-6.2% 的差異,且由親源關係分析可知這 2 年病毒株分別屬於不同的基因型,因此可以推論 2005 年和 2006 年的第三型登革熱病毒並不是同一流行株所造成的連續性傳播。另外,和第三型登革熱病毒之原始株 (H87) 比較,可知這些核苷酸變異多發生在遺傳密碼的第三個核苷酸位置,而呈現非同義的變異。除此之外,我們的結果顯示,2006 年的 8 個登革熱和 2 個出血性登革熱病毒株,在此 290 個核苷酸序列中並沒有明顯的差異性。另外,根據親源關係分析的結果,可知 1998,1999 和 2006 年的台灣第三型登革熱病毒株是屬於第三基因型。值得注意的是,2005 年 2 個台灣病毒株明顯地屬於不同的基因型。由此台灣登革熱第三型病毒的分子流行病學分析,我們可以清楚地瞭解各年之間的登革熱流行,是否為連續性或是地方性登革熱病毒的再次出現,或者是其他國家的境外移入株導致的流行。 |
英文摘要 | Dengue virus serotype 3 (dengue-3) has been classified into five genotypes (I-V) by phylogenetic analysis based on different viral genes. To investigate the genetic variability and evolutionary character of the dengue-3 isolates in southern Taiwan from 2005 to 2006, we analyzed the 290 nucleotides of the core (C) gene of 12 dengue-3 isolates and compared them with the published C gene sequences of global dengue-3 strains available in GenBank, including four isolates from 1998 and one isolate from 1999, from Taiwan. The dengue-3 viruses from 2005 to 2006 were not from continuous spread of an epidemic strain or re-emergence of the 2005 strains in the 2-year period because there was a 5.4-6.2% difference in the 290 nucleotides of the C gene and different genotypes between the 2005 and 2006 strains. Most of the nucleotide changes, compared with a prototype dengue-3 virus, H87, occurred in the third codon position and were non-synonymous mutations occurring naturally in the C gene. In addition, there was no consistent difference in the 290 nucleotides of the C gene between eight dengue fever and two dengue hemorrhagic fever isolates from 2006. The phylogenetic analysis indicates that the isolates from the 1998, 1999 and 2006 Taiwan dengue-3 epidemics are phylogenetically related and belong to genotype III. It was noted that the 2005 Taiwan dengue-3 isolates belong to another genotype. This molecular epidemiology study of dengue-3 viruses in Taiwan helps to elucidate whether there is a continuation of outbreaks in consecutive years, re-emergence of endemic dengue virus, or introduction of strains from other countries. |
本系統中英文摘要資訊取自各篇刊載內容。