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題 名 | Generalized Immunosuppression-Associated Type Kaposi's Sarcoma in a Patient with Severe Refractory Bullous Pemphigoid=發生於頑強水疱性類天疱瘡病人之全身免疫受抑制型卡波西氏肉瘤 |
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作 者 | 莊德揚; 蕭正祥; 朱家瑜; | 書刊名 | 中華皮膚科醫學雜誌 |
卷 期 | 26:2 2008.06[民97.06] |
頁 次 | 頁85-92 |
分類號 | 415.766 |
關鍵詞 | 水疱性類天疱瘡; 卡波西氏肉瘤; Bullous pemphigoid; Interferone-α2b; Kaposi's sarcoma; Lymphocytopenia; |
語 文 | 英文(English) |
中文摘要 | 免疫受抑制型卡波西氏肉瘤的惡化一般認為和免疫受抑制的狀態有關。在此報告一位頑強水疱性類天疱瘡病患於長期接受免疫抑制劑治療六個月後發生卡波西氏肉瘤的病灶,且卡波西氏肉瘤的數目和大小在淋巴球低下的時期突然急遽增加。進一步分析發現該病患的CD4淋巴球減少而HIV抗體呈陰性。我們調降類固醇劑量,且給予病灶內干擾素α2b注射,注射處逐漸變得較不疼痛並出現腫瘤壞死的現象。此外,我們也運用冷凍治療和分期式放射線治療,多數的病灶在六個月後都已消退。 |
英文摘要 | The progression of immunosuppression-associated type Kaposi's sarcoma (KS) is thought to be related to the immunocompromised status. We herein describe a case, who had a quiescent initial lesion of KS developed in the sixth month after receiving immunosuppressive therapy for treating the refractory bullous pemphigoid. The activity of KS increased abruptly during a period of lymphocytopenia. Subsequent analysis showed CD4+ lymphocytopenia and negative anti-HIV antibody. While the dosage of corticosteroid was tapered, intralesional interferon-α2b injection was given as adjuvant therapy. The injected lesions gradually became less painful with obvious necrotic appearance. Cryotherapy and fractional radiotherapy were administered additionally and on the sixth-month of follow-up, it was observed that the majority of KS lesions had regressed. |
本系統中英文摘要資訊取自各篇刊載內容。