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題 名 | 水包油包水(w/o/w)油質佐劑對牛流行熱疫苗抗體消長之影響=Effect of Water-in-oil-in-water (w/o/w) Oil Adjuvant on Long-term Antibody Response of Bovine Ephemeral Fever Vaccine |
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作 者 | 朱純燕; 陳貞妗; 陳銘政; | 書刊名 | 臺灣獸醫學雜誌 |
卷 期 | 33:3/4 2007.12[民96.12] |
頁 次 | 頁211-216 |
分類號 | 437.245 |
關鍵詞 | 牛流行熱; 疫苗; 佐劑; Bovine ephemeral fever; Vaccine; Adjuvant; |
語 文 | 中文(Chinese) |
中文摘要 | 牛流行熱(bovine ephemeral fever; BEF)是由桿狀病毒經庫蠓媒介傳染的牛病毒性疾病,本病在台灣及亞洲國家中呈週期性流行。本研究同時選用Tn73(1984)及Tn88128(1999)之台灣分離株為種毒株,將病毒力價提高為10^8.5 TCID50/mL,以BEI (binary ethylenimine)為不活化劑,加上水包油包水(w/o/w)之雙相油質佐劑研製新疫苗。於田間選用4-6月齡仔牛進行試驗,經基礎免疫後再間隔2-4週補強注射;結果於免疫後4-8週中和抗體力價最高可揚升至512倍,高峰期6-9個月,有效保護力價維持一年,顯著優於最高32倍,高峰期只持續3個月之氫氧化鋁膠疫苗。雙相油質佐劑牯稠度低容易注射,同時具有水質及油質疫苗之優點,可刺激長效型抗體之產生,使抗體高峰期持續至6個月以上,同時能刺激淋巴細胞增殖激發細胞性免疫反應,提供免疫牛群有效保護力。 |
英文摘要 | Bovine Ephemeral Fever (BEE) is a bovine viral disease that is transmitted by culicoides, its outbreak in Taiwan and Southeast Asian countries is periodical. To develop a new oil vaccine, we used both the Tn73 (1984) and Tn88128 (1999) strain as the master seed, elevated the titer of the vaccine to 10^8.5 TCID50/mL, and utilized BEI (binary ethylenimine) for the inactivation and included a special formulated water-in-oil-in-water (w/o/w) adjuvant. In the field trial, this vaccine was tested on 4-6-month-old calves, the animals were given the initial vaccination, followed by a booster dose 2-4 weeks later. The highest titer of the neutralization antibody was observed 4-8 weeks after inoculation, reaching 512× and with the peak lasting for 6-9 months, protecting the animals over a period of 1 year. This new w/o/w vaccine is far more superior to the conventional aluminum hydroxide (Al-gel) vaccine; the latter only gives a titer of 32×, and the peak lasting only 3 months. The w/o/w vaccine is highly syringeable and retains the advantages of both the Al-gel and oil based vaccine, which means, it stimulates not only the long-lasting antibody response but the activity of cell-mediated immunity, providing the effective protection for the herd of cattle. |
本系統中英文摘要資訊取自各篇刊載內容。