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題 名 | 憂鬱症患者之中醫證型與周邊淋巴球mRNA之表現=Depression Patients: Chinese Medicine Viewpoints and mRNA Expressions in Peripheral Lymphocytes |
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作 者 | 藍先元; | 書刊名 | 中醫藥年報 |
卷 期 | 25:2 2007.10[民96.10] |
頁 次 | 頁427-443 |
專 輯 | 中醫藥基因體及免疫學研究 |
分類號 | 413.34 |
關鍵詞 | 重鬱症; 中醫辨證分型; 基因表現; Major depression; Chinese medicine; Gene expression; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究目的為探討憂鬱症由中醫(辯證分型)、西醫(DSM-IV診斷準則)臨床觀點及周邊淋巴球mRNA表現之間的相關性。由精神科門診收集75名符合DSM-IV憂鬱症診斷之患者,進行漢氏憂鬱量表評分及中醫辨證分型,並抽血進行mRNA分析。同時收集75名健康受試者接受相同分析。 目前已收集35名符合DSM-IV憂鬱症診斷標準之個案與35名對照組,由精神科醫師診斷(DSM-IV診斷準則與漢氏憂鬱量表)及中醫師進行中醫辨證分型,再抽取周邊血RNA進行Real time PCR偵測。為更快速的找到影響疾病的基因我們建立一個Real time PCR偵測平臺已完成選殖RGS4、PSAT1、GRM3、SLCIA3、LSM4、GAD1、SHMT2、PPP3CC、GCAT、NRG1、SRR、CHRNA7等基因與其Relative standard curve,使用Real-time PCR同步分析,使用此方法我們可同時觀看一個檢體在一次上機中多基因的表現量差異實驗室已建立整個流程,目前已完成近10個檢體偵測。 25名個案組與對照組在RGS4基因表現與漢氏憂鬱量表分數正相關(r=0.401);而PSAT1基因表現與漢氏憂鬱量表分數呈負相關(r=-0.36)。RGS4之mRNA表現尚未達到統計的顯著性(p=0.10),個案組與對照組的男性在RGS4基因表現則呈現邊緣顯著性PSAT1基因表現於個案組男性(2.37±1.11)與女性(0.98±0.66)有顯著差異(p=0.001),顯示性別可能會造成基因表現差異。此外,我們在過去一年也有一些研究成果發表。 |
英文摘要 | This study was aimed to explore the relationships among the phenotypes of Chinese medicine, Western medicine, and mRNA expression. We enrolled 75 patients with major depressive disorder (by DSM-IV criteria) from psychiatric OPD and 75 healthy controls. The patients were all rated by Hamilton's Depression Rating Scale and subgrouped by Chinese medicine definition. Blood samples were drawn for mRNA expression from all subjects. We have already enrolled 35 drug-free patients with a DSM-IV diagnosis of MDD and 35 healthy controls. All patients were classified by Chinese medicine definitions, and related with Hamilton Depression Rating Scale (HDRS). Messenger RNA was extracted from venous blood of all subjects for gene-expression analysis by real-time PCR. To make gene detection faster and to normalize data among batches, we have set up a real time PCR polygene platform. Novel candidate genes, such as RGS4, PSAT1, GRM3, SLCIA3, LSM4, GAD1, SHMT2, PPP3C, GCAT, NRG1, SRR and CHRNA7, were cloned into plasmid DNA to creative relative standard curves. Using this method, we can examine many genes' expressions in one sample with merely one- time real time PCR. Now we have already done about 10 samples in this platform. Moreover, among 25 patients and 25 age- and gender-matched healthy controls, RGS4 expressions were positively correlated with HDRS scores (r=0.40); and PSAT1, negatively correlated with HDRS (r=-0.36). RGS4 expression levels were marginally higher in male patients than in male controls (p=0.06). PSAT1 expressions differed significantly in male (2.37±1.11) vs. in female patients (0.98±0.66, p=0.001), suggesting gender effects on gene espression. In addition, we have had some publications in the past year. |
本系統中英文摘要資訊取自各篇刊載內容。