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題 名 | 保育類藥材--熊膽替代藥品對小鼠藥理作用之研究=The Replacement of the Conservative Pharmaceutical Medicine-Bear Bile on the Pharmacologic Function in Mice |
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作 者 | 謝長奇; | 書刊名 | 中醫藥年報 |
卷 期 | 25:1 2007.10[民96.10] |
頁 次 | 頁375-401 |
專 輯 | 中醫藥療效評估之研究 |
分類號 | 414.35 |
關鍵詞 | 保育類野生動物; 熊膽; 免疫調節; 抗發炎; Wild animal conservation; Bear bile; Immunomodulation; Anti-inflammation; Bronchial construction; |
語 文 | 中文(Chinese) |
中文摘要 | 陸棲哺乳類野生動物因長久以來民間相信具有療補功效,其皮毛、器官及體肉都成為國人食用的對象,造成強大的獵捕壓力,使族群數量日漸減少,中醫藥界認為部分救命的藥方因此不能處方、調劑,在保護保育類野生動物的前提下,開發其他具有相同或相類似之中藥基源與臨床藥效,以創造保育與醫療雙贏的局面。熊膽調劑於臨床應用上有治療急慢性肝炎、肝腹水、肝硬化、黃疸性肝炎、脂肪肝、膽結石、心臟病、高血壓、腹痛、胃痛、下痢、病毒性咽喉炎、急性扁桃腺炎、喉炎與各種腫痛等,在熊膽列為保育類藥材後而影響其藥材使用後,尋找代用或部分代用之藥品對疾病患者之醫療保健是一項非常有意義的工作。由於兔膽的有效成份較接近熊膽,具有抗惊厥與抗疲勞與鎮咳的作用,對呼吸道過度反應有緩解的趨勢,本研究在探究動物類藥材的取代性研究中,動物類中藥研究學者一致認為,以畜養型動物之藥材取代性較趨近於原藥材,故本研究嘗試使用相近的樣品已作為試驗材料,針對平喘抗發炎等進行試驗。結果顯示,在呼吸道過度反應中,各試驗動物組,經犧牲後熊膽樣品可明顯降低巨噬細胞含量,兔膽樣品高劑量亦可明顯降低巨噬細胞含量。熊膽樣品與兔膽樣品高劑量亦可明顯降低TNF-α含量。體外試驗顯示熊膽樣品與兔膽樣品均具有明顯抑制NO產生與降低誘導發炎激素TNF-α產生,TNF-α會誘導呼吸道與肺臟等上皮細胞ICAM-1與VCAM-1等吸附性蛋白質的表現,影響發炎細胞浸潤於呼吸道中,本試驗指出,發炎細胞激素TNF-α顯著性降低,或許降低了吸附性蛋白質的呈現,進而緩解了發炎細胞的浸潤與呼吸道的過度反應,所以以畜產類動物膽汁作為開發新的藥物資源,值得在未來的研究中繼續進行探討。 |
英文摘要 | Bear is one of the conservation animals, because of the population stress and land capacity, their survival faces the great problem. Committee on Chinese Medicine and Pharmacy, Department of Health want to guidance and assiatance the employment to use the replacement drug in traditional medication. Bear bile can anti-inflammation, reduce bronchial construction and immunomodulation. They are used for two purposes. The first is to correct a deficiency in bile acids because of defective biosynthesis or intestinal conservation and thereby to restore bile acid function. This rationale may be termed replacement therapy. The second is to alter the composition of circulating bile acids and thereby to modulate cholesterol metabolism and/or decrease the cytotoxic of the circulating bile acid pool. In this study, we want to use rabbit bile to be the replacement drug of bear bile in these effects. The data present here indicated bear bile and rabbit bile can significant decrease infiltration in macrophage and down-regulated TNF-α and NO expression. In previous study showed that TNF-α can induce ICAM-1 and VCAM-1 presentation. Our data also present lower TNF-α presentation can down-regulated ICAM-1 and VCAM-1 expression to inhibit the inflammatory cells infiltration, and further reduce the hyperresponsiveness. Use rabbit and other farm animal product to replacement the conservation of animal product like bear will be the great idea in conserved policy. |
本系統中英文摘要資訊取自各篇刊載內容。