頁籤選單縮合
題名 | 中草藥防治癌症之重要機轉與特色--癌症逆轉=Cancer Reversion Model as a Character of Traditional Chinese Medicine for Cancer Prevention |
---|---|
作者 | 鄧文炳; | 書刊名 | 中醫藥年報 |
卷期 | 25:1 2007.10[民96.10] |
頁次 | 頁307-328 |
專輯 | 中醫藥療效評估之研究 |
分類號 | 418.5 |
關鍵詞 | 癌症逆轉; 複方中草藥YGK; 子宮頸癌細胞; 腸鹼性磷酸酵素; 致癌基因E6/E7; 抑癌基因p53; IAP; Cancer reversion; YGK; HeLa cell; Intestinal alkaline phosphatase; E6/E7; p53; |
語文 | 中文(Chinese) |
中文摘要 | 癌症是國人死亡率之第一位,目前由於抗癌策略絕大多數仍然是殺死癌細胞,因此在進行治療的同時,不可否認地多半仍對於人體有程度不一的傷害性。另一方面,研究者開始發現有些高齡老人,其體內其實早已到處充滿著癌細胞,但因為這些癌細胞處於所謂的「休眠狀態」中,並不對人體造成威脅。該等癌細胞甚至還有「長壽癌」之稱。這樣的現象啟示了一種抗癌的新穎可能性,就是設法找尋出一種可使人體內的癌細胞停止在此「休眠狀態」之藥物;若此藥物果能奏效,因為人體並沒有細胞被殺死,則很可能此種療法對於人體的各種副作用也可以降至最低。 所謂癌症逆轉現象(Cancer Reversion),意指腫瘤細胞回復「部分正常」,而成為不具威脅性地可與人體共存的人癌共生現象。特定的中草藥可能藉著啟動腫瘤細胞中的逆轉作用機制,讓癌細胞不表現腫瘤特性,甚至於恢復成相當程度之類似正常細胞。 本實驗室已經利用複方中草藥YGK建立了癌症逆轉的平臺技術,可以直接應用在新的標地藥物之癌症逆轉的篩選。具腫瘤誘發性的HeLa細胞的表面抗原,其具有自磷酸化(Autophosphorylation)活性,是一種細胞的腸鹼性磷酸酵素(Intestinal alkaline phosphatase, IAP),因此本實驗室嘗試解析IAP表現與腫瘤誘發性之間的關係。此外在基因層面的探討,初步實驗結果發現,複方中草藥YGK有增強抑癌基因p53表現的趨勢;而對子宮頸癌主要的E6/E7致病因子則有抑制的功效。在動物實驗方面,注射複方中草藥YGK對於腫瘤細胞生長確實有抑制的效果。以流式細胞儀技術分析複方中草藥YGK對癌細胞的影響,可能並非走細胞毒殺的路徑,因此可以更加的推斷藥物對細胞的作用是進行癌症逆轉的模式。 |
英文摘要 | The cancer is the primary importance of compatriot's death rate, because the anicancer tactics overwhelming majority still kills the cancer cell at present, so while treating, the undeniable ground still has degree no injury of one to the human body mostly. On the other hand, the researcher begins to send to the old man at some advanced ages now, its has actually already been full of cancer cell everywhere, but in the so-called “the dormancy state” because of the cancer cell, do not threaten the human body. These cancer cells even have the claiming of “macrobiotic cancers”. Such a phenomenon has enlightened a kind of novel possibility of resisting the cancer, but try to look for out one to make the cancer cell in the human body stop the medicine of “the dormancy state” here; If this medicine fruit can work, because the human body has no cell to kill, probably this kind of treatment can drop various kinds of side effects of the human body to the lowest. Chinese herbal medicine may be made use of and started, let the cancer cell not display the tumor characteristic, even resume into a similar normal cell analogous to the degree. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。