頁籤選單縮合
題 名 | Effects of Magnesium Sulphate Following Spinal Cord Injury in Rats |
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作 者 | Gok, Beril; Okutan, Ozerk; Beskonakli, Etem; Kilinc Kamer; | 書刊名 | 中國生理學雜誌 |
卷 期 | 50:2 2007.04[民96.04] |
頁 次 | 頁93-97 |
分類號 | 397 |
關鍵詞 | Magnesium; Methylprednisolone; Myeloperoxidase; Spinal cord injury; |
語 文 | 英文(English) |
英文摘要 | Neutrophil infiltration has been implicated in the secondary destructive pathomechanisms after initial mechanical injury to the spinal cord. Tissue myeloperoxidase (MPO) activity has been shown to be an exclusive indicator of the extent of post-traumatic neutrophil infiltration. We have studied the effect of magnesium sulphate on MPO activity after spinal cord injury in rats. Rats ewre randomly allocated into 5 groups. Group 1 was control and normal spinal cord samples were obtained after clinical examination. Forty g-cm contusion injury was introduced to Group 2. Group 3 was vehicle, 1ml of physiologicalsaline was injected post-trauma. Group 4 was given 30 mg/kg methylprednisolone sodium succinate (MPSS) immediately after trauma. Group 5 was given 600 mg/kg magnesium sulphate immediately after trauma. Animals were examined by inclined plane technique of Rivilin and Tator 24 h after trauma. Spinal cord samples obtained following clinical evaluations Magnesium sulphate treatment improved early functional scores and decreased MPO activity. These findings revealed that magnesium suphate treatment possesses neuroprotection on nearly clinical results and on neutrophil infiltration after acute contusion injury to the rat spinal cord. |
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