頁籤選單縮合
題 名 | Resveratrol Protects Vascular Endothelial Cell from Ox-LDL-induced Reduction in Antithrombogenic Activity |
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作 者 | Chen, Ying-jen; Wang, Jong-shyan; Chow, Shu-er; | 書刊名 | 中國生理學雜誌 |
卷 期 | 50:1 2007.02[民96.02] |
頁 次 | 頁22-28 |
分類號 | 361.8 |
關鍵詞 | Trans-resveratrol; Ox-LDL; Endothelial cells; Nonthrombogenecity; Nitric oxide synthase; |
語 文 | 英文(English) |
英文摘要 | Dietary antioxidants are thought to be beneficial in reducing the incidence of coronary heart disease. In this study, the antithrombogenic endothelial cells (EC) defense was investigated in an experiment model in which cultured endothelial cells were incubated with aggregating platelets in the aggregometer. We examined the possible protective effect of trans0reveratrol (RSV) on oxidized low density lipoprotein (ox-LDL)-induced insults on the antithrombogenic activity of the vascular EC. EC were treated with ox-LDL (25-100μg/mg) for 1 h with or without a 30 min-preexposure to RSV. The antiplatelet property of the endothelial cells was then shown by measuring platelet aggregation, □ and CGMP contents in the platelets and EC. Exposure of EC to ox-LDL reduced the antiplatelet aggregating property of EC, and this effect was attenuated by pretreatment with RSV. Father studies revealed that exposure of EC to ox-LDL reduced the protein contents of endothelial nitric oxide synthase (NOS). The effect of ox-LDL on the NOS protein content was abrogated by pretreating EC with RSV. The results suggest that ox-LDL acts via reducing the endothelial NOS activity to suppress the antithrombogenic activity of the EC. |
本系統中英文摘要資訊取自各篇刊載內容。