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題 名 | 白殭菌A1在基因與非基因途徑之致癌潛力剖析=Carcinogenicity Profile of Beauveria Bassiana A1 via Genetic and Epigenetic Toxicities |
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作 者 | 李彥芸; 王雲鶴; 詹玲琴; 蔡寶隆; 游碧堉; | 書刊名 | 植物保護學會會刊 |
卷 期 | 49:1 2007.03[民96.03] |
頁 次 | 頁57-74 |
分類號 | 433.85 |
關鍵詞 | 白殭菌A1; 基因毒性; 非基因毒性; 致癌潛力剖析; Beauveria bassiana A1; Genetic toxicity; Epigenetic toxicity; Carcinogenicity profile; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究以基因與非基因途徑的短期試驗,篩檢白殭菌 (Beauveria bassiana) A1的致變異/致癌潛力,以評估其對人體健康的安全性。動物活體以定量孢子懸浮液經胃管灌注處理;離體試驗則以一定蛋白含量之孢液 (spore lysate) 處理,並經換算為孢子相對劑量,以比較不同試驗體系之間的劑量與毒性反應關係。白殭菌A1在0.5 ~ 10 ’ 106 孢子相對量範圍,對沙門菌組胺酸基因無鹽基置換、框構位移及赭石突變反應;對枯草菌的DNA無傷害影響;對倉鼠卵巢細胞的DNA與染色體亦無顯著之傷害。小鼠口服2.5’108 ~ 1’109 spores/kg bw白殭菌A1,對紅血球母細胞的染色體斷裂及紡綞體結構亦無傷害影響。白殭菌A1經以上四種基因毒性篩檢結果皆無致變異性反應。在非基因途徑方面:白殭菌A1對人體血癌細胞株HL60並無促進細胞增殖的影響,但對細胞凋亡與分化有顯著的促進作用,後兩項標竿意味著白殭菌A1對於啟始癌化的細胞有輕微的抑制優點。白殭菌A1經以上七種短期試驗篩檢及劑量反應關係的剖析結果:此本土蟲生真菌對人體細胞應無致癌之毒性風險,其安全性值得開發為商品化的微生物農藥。 |
英文摘要 | Mutagenicity/carcinogenicity profile of Beauveria bassiana A1 is assessed by both genetic and epigenetic short-term tests. To facilitate dose treatments comparison among different assays, protein contents (mg/treatment) of spore lysate treatments applied in in vitro assays were converted into equivalent spore dose (spores/treatment) based on extraction of 10-5 mg protein content per spore. In the equivalent dose range of 0.5~10 ’ 106 spores/treatment, B. bassiana A1 didn’t induce gene mutation in Salmonella typhimurium by mechanisms of base-pair substitution, frame shift, or ochre mutation. Non-mutagenic responses were resulted from rec assay, sister chromatid exchange assay or mouse micronucleus test.These results suggested that B. bassiana A1 could not possibly initiate the transformation of normal cells via genetic pathway. On the other hand, the results from epigenetic toxicity tests showed that B. bassiana A1 notably promoted the apoptosis and differentiation rather than stimulated the proliferation of human leukemia cells. These end-points implied that B. bassiana A1 has an slightly advantage over the inhibition of initiated cells. In conclusion, above results from seven short-term screening tests and carcinogenicity profile suggested that B. bassiana A1 could have no mutagenicity/carcinogenicity effects on human health and is a valuable biopesticide candidate for commercialization. |
本系統中英文摘要資訊取自各篇刊載內容。