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題 名 | 海鱺體內紅黴素藥物動力學研究=The Pharmacokinetics of Erythromycin in Cobia |
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作 者 | 涂堅; 程健智; 張紹光; 張正芳; 邱芮瑜; 黃淑敏; 張惟茗; | 書刊名 | 行政院農業委員會家畜衛生試驗所研究報告 |
卷 期 | 42 2007.12[民96.12] |
頁 次 | 頁1-10 |
分類號 | 439.19 |
關鍵詞 | 海鱺; 紅黴素; 停藥期; 硬質胃管; Cobia rachycentron canadum; Erythromycin; Withdrawal period; Hard stomach tube; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究為瞭解紅黴素(50 mg/kg)在海鱺體內的殘留時間,評估現有口服投予一日與三日後體內消長情形。本試驗使用硬質胃管餵食的投藥方法,可使投藥劑量準確並明顯減少魚隻緊迫。由結果得知:紅黴素在血清中的濃度,於口服投藥後,分別於約0.5-1小時與18-24小時,兩次達到最高血中濃度(46.7-95.5μg/ mL)。一日投藥組與三日投藥組的血中濃度結果均出現雙峰模式,即以第一次為高,但第二次維持的時間較長,此現象與腸肝循環有關。本試驗最後一次採樣,216小時血中藥物濃度約在0.6-1.8μg/ mL間。在行政院衛生署「動物用藥殘留標準」中並無本藥在水產動物的殘留標準,故無法直接與現有標準比較。但因本藥物於水產動物的停藥期在14-30天間,因此,在參考家畜殘留標準(0.3μg/ mL)後,使用者如能遵循法定停藥期,應無殘留的疑慮。 |
英文摘要 | The erythromycin concentration in the serum of cobia Rachycentron canadum were monitored following oral administration of erythromycin once daily, or once every three days. Our results showed that two-peak erythromycin concentrations (46.7--95.5μg/mL) occurred at 0.5-1 hr and 18-24 hr post oral dosing, respectively. The two-peak pattern of erythromycin concentration in serum, indicating an enterohepatic circulation, was found in both once-a-day and once every three days regimens, which reached the highest concentration at 0.5-1 hr, and retained its highest concentration longer at 18-24 hr. The serum erythromycin concentration decreased to 0.6--1.8 μg/ mL at 216 hr after oral adminstration. Due to the lack of antibiotic residue standards for erythromycin in fish in the Guidelines for Animal Drug Residues by Department of Health in Taiwan, we can not compare our data to that of the present regulation. If the farmers would follow the withdrawal time of 14--30 days for erythromycin recommended by the Aquatic Animal Drugs Guidelines, the antibiotic residues in cobia should be less than 0.3 μg/g, which was equal to the maximal residue of erythromycin in pig and cow tissues allowing for human consumption in the Guidelines for Animal Drug Residues in Taiwan. |
本系統中英文摘要資訊取自各篇刊載內容。