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頁籤選單縮合
| 題 名 | 水產藥物在海鱺體內藥物動力學研究=The Pharmacokinetics of Aquatic Antimicrobials in Cobia |
|---|---|
| 編 次 | 1 |
| 作 者 | 涂堅; 張紹光; 張正芳; 黃淑敏; 宋玫璟; 郭鴻志; 楊嘉宏; 程健智; 張惟茗; | 書刊名 | 行政院農業委員會家畜衛生試驗所研究報告 |
| 卷 期 | 41 民95.12 |
| 頁 次 | 頁123-134 |
| 分類號 | 439.19 |
| 關鍵詞 | 海鱺; 安默西林; 安比西林; 停藥期; Cobia rachycentron canadum; Amoxicillin; Ampicillin; Withdrawal period; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 本研究嘗試瞭解安默西林(40 mg/kg)與安比西林(20 mg/kg)在海鱺體內可能殘留的時間,協助評估現有停藥期是否適用。在本實驗中研究者以硬質胃管餵食建立新的投藥方法,使投藥劑量準確並明顯減少魚隻緊迫。對藥物分析而言,研究者改良其他研究者的分析方法、如縮短萃取時間、減少廢有機溶液的產生,並以變更酸鹼值的方式改善分析。對於上述二藥物的停藥期而言,雖然無法直接與現有動物用藥品殘留容許量標準資料比較,但由分析結果得知:安比西林與安默西林在肌肉中的殘留濃度,於投藥48 小時後,均低至或接近行政院衛生署動物用藥殘留標準(0.01μg/mL),且兩者於血液中亦均低於最低訂量極限。 |
| 英文摘要 | The purpose of this study was to evaluate the possible residue time of amoxicillin and ampicillin in tissues of cobia Rachycentron canadum after a single oral dose and to help confirm withdrawal period of those drugs. The author used hard stomach tube for drug administration at each study. This method significantly increases the accuracy of drug administration and decreases the stress of experimental fish. The authors also modified other researches’ analytic methods, such as decrease of extraction time, decrease of amount of waste organic solvent, and changes of pH in mobile phase. All mentioned improvements made the analysis more easily to operate than before. There is no maximum residue levels can be compared directly at present time. Our HPLC results indicated that the muscle and blood concentration for ampicillin and amoxicillin were lower than or close to 0.01μg/ml (maximal residue allowed for animal drugs by Department of Health) 48 hours after a single oral administration. |
本系統中英文摘要資訊取自各篇刊載內容。