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題 名 | Interleukin-1 β in Oral Submucous Fibrosis, Verrucous Hyperplasia and Squamous Cell Carcinoma Tissues=口腔粘膜下纖維化症、上皮疣狀增生及鱗狀細胞癌組織之介白質-1 β 之研究 |
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作 者 | 蔡吉政; 陳慶長; 林正仲; 陳中和; 林聰勝; 謝天渝; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 15:9 1999.09[民88.09] |
頁 次 | 頁513-519 |
分類號 | 416.93 |
關鍵詞 | 口腔粘膜; 纖維化症; 上皮疣狀增生; 鱗狀細胞癌組織; 介白質-1 β; Interleukin 1-β; Oral submucous fibrosis; Oral squamous cell carcinoma; |
語 文 | 英文(English) |
中文摘要 | Interleukin-l β(IL-1β)是被證實具有多重作用之發炎性介質。它的來源細胞多達二十多種,而它作用也涵蓋了免疫細胞及非免疫細胞,在內皮方面,它可使發炎細胞易於自血中移動至發炎組織中;在纖維細胞方面,可藉之調節細胞外基質之合成與分解;在骨方面,可間接造成骨吸收並抑制骨生成。由此可知IL-1β角色之多樣性,但是目前對於IL-1 β之研究多針對體液及單一細胞培養之培養液中IL-1β含量之多寡,較少有關於組織塊中IL-1β總含量之研究,尤其對口腔粘膜病灶中其組織中之IL-1β總含量的研究更是缺乏。因此,本研究乃利用酵素免疫分析法(ELISA)來加以測定口腔粘膜下纖維化症、鱗狀細胞癌及上皮疣狀增生組織塊中IL-1β之含量與正常口腔粘膜組織內之IL-1β含量作統計學上之比較,並以免疫組織化學染色法檢測代表性口腔組織以了解病灶區是否為主要的IL-1β來源。結果正常口腔粘膜組織內之IL-1β含量為1.07 ± 0.53 pg/mg tissue,口腔粘膜下纖維化症之IL-1β含量為0.76±0.56 pg/mg tissue,鱗狀細胞癌之IL-1β含量為4.37±0.87 pg/mg tissue,上皮疣狀增生之IL-1β含量為3.97 ± 1.93 pg/mg tissue。以Mann-Whitney U-test分析顯示口腔粘膜下纖維化症與正常口腔粘膜之IL-1β含量無統計學上差異 (p>0.05),而鱗狀細胞癌及上皮疣狀增生則與正常口腔粘膜之IL-1β含量有統計學上顯著的差異 (p<0.001),但鱗狀細胞癌及上皮疣狀增生並無組間差異。免疫組織化學染色的觀察結果與酵素免疫分析法的結果一致,IL-1β的強烈陽性反應只見於鱗狀細胞癌,及上皮疣狀增生組織。以上結果顯示鱗狀細胞癌及上皮疣狀增生組織之IL-1β含量明顯高於口腔粘膜下纖維化症與正常口腔粘膜,表示IL-1β在組織塊中總含量與疾病之細胞變性呈現關聯性。另一方面,正常口腔粘膜之IL-1β與口腔粘膜下纖維化症之IL-1β含量無明顯差異,顯示IL-1β總含量在口腔粘膜下纖維化症的病程上無顯著變化,且經分析發現口腔粘膜下纖維化症其組織塊中IL-1β含量與其疾病嚴重度無關,不能依據IL-1β含量作為纖維化嚴重程度之參考。 |
英文摘要 | Interleukin-1β (IL-1β) has been proven to be a multi-effect mediator of inflammation including in the promotion of inflammatory cells to move from blood to inflamed tissues, the regulation of the synthesis and decomposition of extra-cellular matrix, and indirectly in causing bone resorption and inhibition of bone growth. In this study, the amounts of IL-1β in the biopsied specimens of normal oral mucosa, oral submucous fibrosis (OSF), oral squamous cell carcinoma (OSCC), and verrucous hyperplasia (VerH) were quantified by ELISA. The results showed that the amounts of IL-1β (pg per mg tissue, mean ± SD) in normal oral mucosa, OSF, OSCC, and VerH were 1.07 ± 0.53, 0.76 ± 0.56, 4.37 ± 0.87 and 3.97 ± 1.93 respectively. There were no significant differences (p>0.05, Mann-Whitney U Test) between the amounts of IL-1β in normal oral mucosa and OSF, and between VerH and OSCC. However, a significant difference in IL-1β level was found (p<O.OOi) between normal oral mucosa and OSCC or VerH. Immunohistochemistry staining technique using antibody against IL-1β showed positive staining in hyperplastic epithelium (VerH) and tumor cells of OSCC. These results might suggest a correlation between the amounts of IL-1β in oral precancerous and cancerous lesions and cell transformation. On the other hand, the amount of IL-1β did not change significantly as OSF progressed. Thus, IL-1β levels may not be useful to gauge the seriousness of fibrosis, but the gradual increase in IL-1β level from normal oral mucosa through VerH to OSCC suggests that IL-1β may play an important role in oral carcinogenesis. |
本系統中英文摘要資訊取自各篇刊載內容。