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頁籤選單縮合
題名 | Long-Term Complications of Living Kidney Donation=活體腎移植捐贈者的長期併發症 |
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作者姓名(中文) | 廖英全; 吳明儒; 陳呈旭; 鄭志雄; 賀昊中; 楊啟瑞; 徐國雄; | 書刊名 | 臺灣腎臟醫學會雜誌 |
卷期 | 21:2 2007.06[民96.06] |
頁次 | 頁112-117+165 |
分類號 | 416.273 |
關鍵詞 | 慢性腎衰竭; 高血壓; 腎移植; 活體捐贈者; 蛋白尿; Chronic renal failure; Hypertension; Kidney transplantation; Living donor proteinuria; |
語文 | 英文(English) |
英文摘要 | Background: Some studies show that individuals with decreased renal mass may suffer from higher risk in developing proteinuria, hypertension and chronic renal failure in the long run. Materials and methods: We conducted a cross-sectional, observational study to evaluate living kidney donors of our hospital over the past 22 years. Data from medical charts were retrieved at donation and last follow-up. Results: There were 10 male and 21 female donors. The mean age at donation was 45.3±13.5 years old. The serum creatinine at donation was 0.86±0.21 mg/dl while the serum creatinine at follow-up was 1.32±0.66 mg/dl. (P=0.008). The mean duration of follow-up was 8.03±6.3 years. The mean age at follow-up was 54.7±17.5 years old. At last follow-up, 6 patients (19.35%) have hypertension. Four patients (12.9%) have proteinuria. Two patients (6.45%) have estimated glomerular filtration rate (eGFR) less than 30 ml/min. The mean eGFR at follow-up was 56.8±17.5 ml/min. The occurrence of hypertension, proteinuria and chronic renal failure of these donors were not related to their gender, creatinine level at donation and age at donation except the association between hypertension and age at donation (P=0.017). Hypertensive donor was older (74.8 vs. 49.9 years, P=0.001) and with longer duration of follow-up (16.8 vs. 5.9 years, P=0.001). On the other hand, donor with proteinuria were also of older age (73.3 vs. 52.0 years, P=0.017) and with longer duration of follow-up (17.0 vs. 6.7 years, P=0.007). Linear regression analysis revealed that both increasing age and longer duration post surgery were associated with a lower eGFR (R^2=0.162, P=0.025 for age; R^2=0.2688, P=0.003 for duration). The multiple regression model showed a borderline statistical significance in the duration post surgery as a predictor of decreased eGFR (P=0.053) while the age at follow-up was not (P=0.96). Both hypertension and proteinuria were related to decreased eGFR (P=0.024 and P=0.039, respectively). Donors with more risk factors (either hypertension or proteinuria) were associated with a lower eGFR (P=0.016). Conclusion: A significant proportion of living donors may develop proteinuria and/or hypertension in the long run, which was related to either aging or increasing duration after kidney donation. |
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