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頁籤選單縮合
題名 | 肺支氣管發育不全的新觀念--血管生成不良假說=Bronchopulmonary Dysplasia (BPD) --Vascular Hypothesis of BPD |
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作者 | 林毓志; 林其和; | 書刊名 | 中華民國兒童胸腔醫學會雜誌 |
卷期 | 5:3 2007.05[民96.05] |
頁次 | 頁117-121 |
分類號 | 417.5171 |
關鍵詞 | 肺支氣管發育不全; 血管內皮細胞生長因子; 內皮細胞一氧化氮合成媒; 一氧化氮; 血管生長; Bronchopulmonary dysplasia; Vascular endothelial growth factor; Endothelial nitric oxide synthase; Nitric oxide; Angiogenesis; Alveolarization; |
語文 | 中文(Chinese) |
英文摘要 | Bronchopulmonary dysplasia (BPD) is the chronic lung disease of infancy that follows ventilator and oxygen therapy for acute respiratory failure after premature birth. Recently, infants with “New BPD” have a far different clinical course and pathology than had been observed in infants with “classic BPD” in the past. Infants with “New BPD” now have less severe acute respiratory disease, and at autopsy, lung histology is predominantly characterized by arrested lung development, including impaired alveolar and vascular growth. Mechanisms that inhibit distal lung growth are poorly understood, but recent clinical and laboratory studies suggest that impaired vascular endothelial growth factor signaling and reduced nitric oxide (NO) production decreases alveolar and vessel growth in the developing lung, features observed in experimental oxygen-induced BPD. Therapy enhancing VEGF/NO signaling may be a potential way to treat diseases associated with impaired alveolar structures. |
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