查詢結果分析
來源資料
相關文獻
- Distant Failure Patterns of Resected Stage I Non-small Cell Lung Cancer: A Long-term Follow-up
- 探討手術後病人對疼痛護理及疼痛控制的滿意度及其影響因素
- 上頜竇之術後囊腫
- Epiglottic Hematoma Secondary to Endotracheal Intubation
- 高雄榮總術後病患自控式止痛法之評估
- 術後疼痛
- Acute Postoperative Aggravation of Radiculopathy as a Complication of Free Fat Transplantation in Lumbar Disc Surgery: Case Report
- Unexpected Transurethral Resection of Prostate Syndrome Complicated with Acute Myocardial Infarction during Transurethral Incision Procedure--A Case Report
- 手術後嚴重黃疸之選擇性膽紅素吸附血漿灌流療法:一例報告
- Comparison of PCA Nalbuphine and Morphine in Chinese Gynecologic Patients
頁籤選單縮合
題名 | Distant Failure Patterns of Resected Stage I Non-small Cell Lung Cancer: A Long-term Follow-up=第一期非小細胞型肺癌病人術後發生遠端轉移之型態:長期追蹤分析 |
---|---|
作者 | 洪榮志; 吳玉琮; 黃敏雄; 黃炳勳; 王良順; 許文虎; | 書刊名 | 臺灣外科醫學會雜誌 |
卷期 | 39:5 民95.09-10 |
頁次 | 頁227-235 |
分類號 | 416.224 |
關鍵詞 | 非小細胞型肺癌; 術後; 遠端轉移; Stage I non-small cell lung cancer; Distant failure; Predictor; Survival; |
語文 | 英文(English) |
中文摘要 | 手術切除是第一期非小細胞型肺癌之最佳治療方式,而遠端轉移是第一期非小細胞型肺癌致命及治療失敗最常見的原因。本研究分析第一期非小細胞型肺癌病人術後之臨床病理變項,轉移位置,無病期及存活率之間的關係。以1980年至2000年台北榮總之155位第一期非小細胞型肺癌術後發生遠端轉移的病人為對象,對其臨床病理變項作追溯性的紀錄,並與無病期,存活率及其預測因子作分析。病人追蹤期間之中位數為20.5個月(平均值:25.4±19.5 months)。遠端轉移發生的時間之中位數為11.5個月(95% CI為9.8~13.6個月)。二年及五年之無病率分別是12.9和1.3%。二年及五年之存活率分別是43.2%和6.5%。轉移至骨頭的有52位病人(33.5%),肺內轉移的有39位(25.2),轉移至腦部的有37位(23.9%),轉移至肝臟的有17位(11.0%)。155位病人中,35位(22.6%)有第二處遠端轉移。轉移至骨頭的13位(37.1%),肺內轉移的有8位(22.9%)。多變量分析顯示腫瘤大小和組織分類對無病率有顯著影響(p=0.003,0.003)。腫瘤大小,組織分類和第一處轉移的位置對存活率有顯著影響(p=0.0034,<0.001,0.009)。鱗狀上皮癌之病人,存活率較腺癌病人差(hazard ratio, 1.90; 95% CI是1.29~2.79)。第一處轉移至腦及骨頭的病人存活率較肺內轉移的病人差(hazard ratio 2.04和1.80,95% CI是1.25~3.35及1.16~2.77)。第一期非小細胞型肺癌病人術後若發生轉移則存活率很差。腫瘤大小是對無病率和存活率的重要預測因素。 |
英文摘要 | Objective: Resection is the best treatment for patients with Stage I non-small cell lung cancer (NSCLC). Distant metastasis is the most frequent cause of treatment failure and cause of death in NSCLC. The goal of this study was to evaluate the clinicopathologic characteristics, pattern of distant failure, disease-free time and survival in patients with resected Stage I NSCLC. Methods: We retrospectively reviewed the clinicopathologic characteristics of 155 patients of resected Stage I NSCLC with distant failure in Taipei Veterans General Hospital between 1980 and 2000. Disease-free time, survival, and their predictors were analyzed. Results: Patients were followed up for 20.5 months (mean, 25.4 19.5 months). Distant failure occurred at 11.5 months (median, 95% CI: 9.8 to 13.6 months). The disease-free rate and survival at 2 and 5 years were 12.9% and 1.3%, and, 43.2% and 6.5%, respectively. The sites of distant failure were bone in 52 (33.5%), lung to lung in 39 (25.2%), brain in 37 (23.9%) and liver in 17 (11.0%). A second site of distant failure was noted in 35 of 155 patients (22.6%): bone in 13 (37.1%) and lung to lung in 8 (22.9%). Multivariate analysis showed that tumor size and histological type had significant impact on disease-free survival (P=0.003, 0.003), and tumor size, histological type and first site of distant failure had significant impact on overall survival (P=0.034, <0.001, 0.009). Patients with squamous cell carcinoma survived shorter than patients with adenocarcinoma (hazard ratio 1.90, 95% CI: 1.29~2.79). Patients with the first distant failure site being brain and bone had significantly worse survival than those with lung to lung distant failure (hazard ratio: 2.04 and 1.80, 95% CI: 1.25-3.35, and 1.16-2.77). Conclusions: The survival was poor for patients of resected Stage I non-small cell lung cancer after distant failure. Tumor size is the significant predictor for both disease-free and overall survival. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。