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題名 | 白朮炮製研究=Study on the Processing of Atractylodis Rhizoma |
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作者 | 王靜瓊; Wang, Ching-chiung; |
期刊 | 中醫藥年報 |
出版日期 | 20061000 |
卷期 | 24:3 民95.10 |
頁次 | 頁121-155 |
分類號 | 414.4 |
語文 | chi |
關鍵詞 | 白朮; 炮製; 胃保護炎作用; 倍半帖類; 毒性試驗; Atractylodis rhizoma; Processing of Chinese herb; Sesquiterpenoids; Anti-ulcer effects; Toxicity; |
中文摘要 | 本研究購入全國北、中、南區市售白朮共38件,含6件生品,再以HPLC分析檢測其atractylon及atractylenolides II, III之含量,發現各區之間的含量差異大,其全國平均值如下:市售生品平均之atractylon含量為2.873 mg/g及炮製品平均為1.803 mg/g;市售生品之atractylenolide II為0.693 mg/g及atractylenolide III為1.532 mg/g;炮製品:atractylenolide II為0.878 mg/g及atracylenolide III為1.914 mg/g。 白朮自行炮製結果顯示:潤製及炒製10分鐘後atractylon會明顯下降,atractylenolides II及III會上升,推測白朮之成分,因加工,使atractylon氧化成atractylenolides II及III,其中以清炒及紅土炒5分鐘之白朮含倍半帖總量最高。然而蒸製白朮結果顯示,加入不同輔料蒸製後,成分變化不明顯,且水蒸與米泔水蒸之總含量較高,因而建議可用水蒸白朮軟化組織即可。 另,以生品、紅土及灶心土炒5分鐘及清炒30分鐘白朮(白朮炭)之萃取物,進行胃幽門結紮法之胃保護評估,結果顯示紅土炒之白朮片對胃保護最為明顯,因而推測紅土炒之白朮確實可增強保護胃壁之作用,但與其酸鹼度無直接之關係,適合於白朮之炮製。Ames毒性試驗之評估結果,焦白朮與白朮炭不會有致突變之作用。 |
英文摘要 | The 38 kinds of commercial Atractylodis Rhizoma (included 6 kinds of raw Atractylodis Rhizoma) were purchased from Taiwan and the quantitative analysis of sequiterpenoids (atractylon, atractylenolids I, II, III) was performed by HPLC system. The results showed, the average content of atractylon, atractylenolides II and III was 2.873, 0.693, 1.532 mg/g in raw commercial Atractylodis Rhizoma and 1.803, 0.878, 1.914 mg/g in processed, respectively. In the present investigation, we collected three kinds of commercial Atractylodis Rhizoma, processed by ourselves and detected the content of sesquiterpenoids (atractylon, atractylenolids I, II, III). The results showed, the amount of atractylon in Atractylodis Rhizoma was decreased and atractylenolides II and III increased by soaked and stir-fired processing. However, Atractylodis Rhizoma was stir-fired for 5 min, which richly contented with total sesquiterpenoids. The amount of total sesquiterpenoids was not significantly changed in steamed Atractylodis Rhizoma. Therefore, we suggested that steam is a good method to softer Atractylodis Rhizoma. The other hand, the anti-ulcer effects and toxic analysis of Atractylodis Rhizoma were evaluated between raw and processed. The results showed, Atractylodis Rhizoma was stir-fired with red soil for 5 min which could more prevent the ulcer in rats than the other processed methods. Moreover, raw and processed Atractylodis Rhizoma do not showed significant mutagenicity and toxicity in Ames (TA 98) tests and acute toxicity assay via oral administration. In according to the results, we suggested the best-processed method of Atractylodis rhizoma was stir-fired with red soil for 5 min. |
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