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題 名 | 辛夷散對過敏性鼻炎治療臨床療效評估(2)=Study the Effects of Shin-Yi-San on the Treatment of Allergic Rhinitis (2) |
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作 者 | 楊賢鴻; | 書刊名 | 中醫藥年報 |
卷 期 | 24:1 民95.10 |
頁 次 | 頁357-397 |
專 輯 | 中醫藥療效評估之研究 |
分類號 | 414.51 |
關鍵詞 | 過敏性鼻炎; 辛夷散; 細胞激素; Allergic rhinitis; Shin-Yi-San; Cytokine; |
語 文 | 中文(Chinese) |
中文摘要 | 過敏性鼻炎為臺灣重要的疾病,儘管現代醫學對過敏性鼻炎有良好之療效,但是對於該病在臨床上的反覆再發,則較少有好的辦法,從我們過去的研究及發表,我們發現中藥對過敏性鼻炎治療有良好的療效,且此療效與免疫調節有密切的關係,由於先前的實驗足以融合三個中藥複方為治療藥物,且研究設計並非為雙盲設計,因此我們在本次研究設計中,將以上次研究用藥之主要成方「辛夷散」作為臨床療效評估的用藥,且將研究設計為雙盲實驗,實驗中我們共收集病患總數108人,完成整體實驗計60位,其中包括實驗組40位、對照組20位。實驗結果我們發現,實驗組臨床症狀、鼻阻力、鼻腔截面積於服藥後顯著改善,但是對照組則沒有統計上之差異。進一步檢視塵蟎特異性免疫球蛋白E:Der P1及Der P2,實驗組於治療後顯著下降,但是對照組則沒有統計上之差異。T淋巴球細胞激素之分泌檢測,我們發現實驗組IL-10於治療後顯著上升,但是IL-4;IL-13及IFN-γ則沒有影響,至於對照組則沒有統計上之差異。嗜中性白血球活性之檢測,我們發現實驗組sICAM-1及IL-8於治療後顯著上升,但是PGE₂及LTC₄則沒有影響,至於對照組都沒有統計上之差異。由本實驗結果我們認為中藥複方「辛夷散」治療過敏性鼻炎可有效改善臨床症狀,且此症狀之改善是經由免疫調節作用而達成。 |
英文摘要 | Allergic rhinitis an important disease in Taiwan due to its high prevalence rate, through there are satisfy of clinical treatment by western medicine but the recurrent attack of allergic rhinitis also an important problem in Taiwan. From our previous studies, we found that Chinese herbs was benefit to the treatment of allergic rhinitis via the immunomodulatory effects, because of our previous studies combined with 3 formulas and not doing under the randomized trial, so we design this study using one formula of herbal medicine (shin-yi-san) for the treatment of allergic rhinitis by a randomized double blind clinical trial. In this study we enrolled 108 patients and 60 patients complete the study with 40 in study group and 20 in placebo group. As the results we found there were significant change in symptomatic score; lower the nasal resistence and enhanced the distance range of nasal cavity after treated with herbal medicine but not in placebo group, the assay of specific IgE amound of DerP1 and Der P2, we found both of them decreased with significant change in study group but not in placebo group, further assay the cytokine production form T lymphocytes, we found, IL-10 was increased after treated with herbal medicine in study group, but we did not found any change of IL-4; IL-3 and IFN-γ production, in neutrophil activity assay, we found sICAM-1 and IL-8 was increased after treated with herbal medicine in study group, but we did not found any change of PGE₂ and LTC₄ and all the cytokine production of placebo group. As the results, we found herbal medicine (shin-yi-san) is benefit to the treatment of allergic rhinitis with the mechanism of immunomodulatory effects. |
本系統中英文摘要資訊取自各篇刊載內容。