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題 名 | 以BP180 NC16a酵素連接免疫吸附反應作為診斷類天疱瘡的輔助工具=Using BP180 NC16a Enzyme-Linked Immunosorbent Assay as an Adjunct Diagnostic Tool for Bullous Pemphigoid |
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作 者 | 黃正宏; 陳志強; 王啟瑞; 張雲亭; 劉漢南; | 書刊名 | 中華皮膚科醫學雜誌 |
卷 期 | 24:3 民95.09 |
頁 次 | 頁163-170 |
分類號 | 415.766 |
關鍵詞 | 類天疱瘡; 水疱; BP180; Bullous pemphigoid; Enzyme-linked immunosorbent assay; ELISA; Noncollagenous 16a domain; NC16a; |
語 文 | 中文(Chinese) |
中文摘要 | 類天疱瘡乃因體內產生對抗BPAg1(BP230)及BPAg2(BP180)的自體免疫抗體所引起的後天性表皮下水疱病變,其好發於老年人族群。近來利用酵素連接免疫吸附反應(Enzyme-Linked Immunosorbent Assay, ELISA),可針對引發自體免疫抗體反應的抗原(BP180)上的NC16a區域做測定,其敏感性及特異性都很高。不過BP180 NC16a ELISA在中國人類天疱瘡的運用,卻未曾被研究過。本研究針對49位類天疱瘡病患及非類天疱瘡的62位病人進行BP180 NC16a ELISA。類天疱瘡病患中有36位(73.5%)其BP180呈現陽性反應,而在非類天瘡的病人中,只有3位(4.8%)其BP180呈現陽性反應,所以利用BP180 NCl6a ELISA在診斷類天疱瘡時,其敏感度(sensitivity)為73.5%,其特異性(speoificity)為95.2%。在疾病活性監測方面,共有5位病患在診斷當時及治療過後抽血做BP180 ELISA的追蹤,發現疾病活性與BP180效價(titer)呈現正向相關的關聯性。我們認為BP180 NC16a ELISA可以做為類天疱瘡診斷以及監測疾病的輔助工具。 |
英文摘要 | Bullous pemphigoid (BP) is an acquired autoimmune subepidermal blistering disease caused by autoantibodies against bullous pemphigoid antigen 1 (BPAg1, 230kD) and bullous pemphigoid antigen 2 (BPAg2, 180kD). It usually affects an elderly population. Recently, a novel commercial enzymelinked immunosorbent assay (ELISA) against the noncollagenous (NC) 16a domain of BP180 has been established and found to be extremely sensitive and specific. Up until now, the usefulness of BP 180NC16a ELISA in the diagnosis of BP in Chinese population has never been reported. In this study, BP180NC16a ELISA was performed in 49 patients with BP and 62 non-BP patients. Thirty-six (73.5%) sera from BP patients were positive, while only 3(4.8%) sera from other non-BP patients exceeded the cut-off value. Thus the sensitivity and specificity of BP180 NC16a ELISA were 73.5% and 95.2%, respectively. The correlation between ELISA scores and disease activity along the time course was examined in 5 BP patients, and there was a positive correlation between ELISA scores and disease activity. These findings indicate that BP180 NC16a ELISA may be an adjunct tool for the initial diagnosis and monitoring of patients with BR. |
本系統中英文摘要資訊取自各篇刊載內容。